Vitamin E

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Cambridge Heart Antioxidant Study (CHAOS)[1] -
lack of dose-response gradient
  Nonfatal MI
Vitamin E 800 IU/day 2.0% (11/546)
Vitamin E 400 IU/day 0.6% (3/489)
Placebo 4.2% (41/967)

In biochemistry, vitamin E is a "generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. by virtue of the phenolic hydrogen on the 2h-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids."[2]


In 2005, a meta-analysis concluded that Vitamin E supplementation may actually be harmful when used for the prevention of vascular disease.[3] Sales of vitamin E dropped after the publication of this meta-analysis.[4]

References

  1. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ (March 1996). "Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)". Lancet 347 (9004): 781–6. DOI:10.1016/S0140-6736(96)90866-1. PMID 8622332. Research Blogging.
  2. Anonymous (2023), Vitamin E (English). Medical Subject Headings. U.S. National Library of Medicine.
  3. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (January 2005). "Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality". Ann. Intern. Med. 142 (1): 37–46. PMID 15537682[e]
  4. Tilburt JC, Emanuel EJ, Miller FG (2008). "Does the evidence make a difference in consumer behavior? Sales of supplements before and after publication of negative research results.". J Gen Intern Med 23 (9): 1495-8. DOI:10.1007/s11606-008-0704-z. PMID 18618194. PMC PMC2518024. Research Blogging.