Chronic kidney disease: Difference between revisions
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==Signs and symptoms== | ==Signs and symptoms== | ||
[[Uremia]], "the illness accompanying kidney failure", may have subtle manifestations when the [[glomerular filtration rate]] falls below 60 ml/min/1.73 m<sup>2</sup> <ref name="pmid17898101">{{cite journal |author=Meyer TW, Hostetter TH |title=Uremia |journal=N. Engl. J. Med. |volume=357 |issue=13 |pages=1316–25 |year=2007 |pmid=17898101 |doi=10.1056/NEJMra071313}}</ref> | [[Uremia]], "the illness accompanying kidney failure", may have subtle manifestations when the [[glomerular filtration rate]] falls below 60 ml/min/1.73 m<sup>2</sup> <ref name="pmid17898101">{{cite journal |author=Meyer TW, Hostetter TH |title=Uremia |journal=N. Engl. J. Med. |volume=357 |issue=13 |pages=1316–25 |year=2007 |pmid=17898101 |doi=10.1056/NEJMra071313}}</ref> | ||
==Treatment== | |||
===Medications=== | |||
====Angiotensin inhibition==== | |||
Angiotensin can be inhibited with either [[angiotensin converting enzyme inhibitor]]s or [[angiotensin II receptor antagonist]]s. | |||
==References== | ==References== | ||
Revision as of 08:23, 5 January 2008
Chronic kidney disease is defined as "kidney damage or glomerular filtration rate (GFR) <60 mL/min/1.73 m(2) for 3 months or more, irrespective of cause. Kidney damage in many kidney diseases can be ascertained by the presence of albuminuria, defined as albumin-to-creatinine ratio >30 mg/g in two of three spot urine specimens."[1]
Classification
There are five stages:[1]
- Stage 1 - glomerular filtration rate is 90 ml/min/1.73 m2 or more
- Stage 2 - glomerular filtration rate is 60-89 ml/min/1.73 m2
- Stage 3 - glomerular filtration rate is 30-59 ml/min/1.73 m2
- Stage 4 - glomerular filtration rate is 15-29 ml/min/1.73 m2
- Stage 5 - glomerular filtration rate is less than 15 ml/min/1.73 m2 or on dialysis
Signs and symptoms
Uremia, "the illness accompanying kidney failure", may have subtle manifestations when the glomerular filtration rate falls below 60 ml/min/1.73 m2 [2]
Treatment
Medications
Angiotensin inhibition
Angiotensin can be inhibited with either angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists.
References
- ↑ 1.0 1.1 Levey AS, Eckardt KU, Tsukamoto Y, et al (2005). "Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)". Kidney Int. 67 (6): 2089–100. DOI:10.1111/j.1523-1755.2005.00365.x. PMID 15882252. Research Blogging.
- ↑ Meyer TW, Hostetter TH (2007). "Uremia". N. Engl. J. Med. 357 (13): 1316–25. DOI:10.1056/NEJMra071313. PMID 17898101. Research Blogging.