Diastolic heart failure: Difference between revisions

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Digoxin may reduce the combined outcome of death or hospitalization due to worsening heart failure according the results of the ancillary trial of patients with preserved ejection fraction in a larger [[randomized controlled trial]] of treating patients with heart failure.<ref name="pmid9036306">{{cite journal| author=| title=The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group. | journal=N Engl J Med | year= 1997 | volume= 336 | issue= 8 | pages= 525-33 | pmid=9036306  
Digoxin may reduce the combined outcome of death or hospitalization due to worsening heart failure according the results of the ancillary trial of patients with preserved ejection fraction in a larger [[randomized controlled trial]] of treating patients with heart failure.<ref name="pmid9036306">{{cite journal| author=| title=The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group. | journal=N Engl J Med | year= 1997 | volume= 336 | issue= 8 | pages= 525-33 | pmid=9036306  
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=9036306 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=9036306 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
==Prognosis==
Diastolic dysfunction, even in the absence of clinical [[heart failure]], increases mortality.<ref name="pmid12517230">{{cite journal| author=Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ| title=Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. | journal=JAMA | year= 2003 | volume= 289 | issue= 2 | pages= 194-202 | pmid=12517230
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=12517230 }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=12954043 Review in: ACP J Club. 2003 Sep-Oct;139(2):51] <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>


==References==
==References==
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Revision as of 11:50, 1 March 2010

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In medicine and physiology, diastolic heart failure or diastolic dysfunction is "heart failure caused by abnormal myocardial relaxation during diastolic leading to defective cardiac filling."[1]

Up to 40% of patients with heart failure may not have evidence of systolic dysfunction.[2]

Diagnosis

Echocardiography for detecting diastolic heart failure among patients with left ventricular preatrial contraction pressure and normal ejection fraction[3]
Finding Sensitivity Specificity
Mitral annular velocity (E/e') > 13 mm Hg 70% 93%
Left atrial volume index (LAVi) > 31 mL/m2 78% 76%
Pulmonary artery systolic pressure (PAP) 80% 64%
E/e' or LAVi* 87% 88%
Notes:
* E/e' > 13 mm Hg or LAVi > 31 mL/m2 with E/e' > 7 mm Hg

Echocardiography may detect diastolic heart failure (see table).[3]

The the ratio of peak early (E) or passive diastolic filling and peak atria1 (A) velocities (E/A ratio) of < 0.6 is less sensitive.[4]

Treatment

Digoxin may reduce the combined outcome of death or hospitalization due to worsening heart failure according the results of the ancillary trial of patients with preserved ejection fraction in a larger randomized controlled trial of treating patients with heart failure.[5]

Prognosis

Diastolic dysfunction, even in the absence of clinical heart failure, increases mortality.[6]

References