Tetrahydrofolate dehydrogenase/Definition: Difference between revisions
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imported>Howard C. Berkowitz (New page: <noinclude>{{Subpages}}</noinclude> An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing red...) |
imported>Howard C. Berkowitz No edit summary |
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An enzyme of the oxidoreductase class that catalyzes the reaction 7,8- | An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihydrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and [[NADPH]]+, producing reduced folate for [[amino acid]] metabolism, [[purine]] ring synthesis, and the formation of deoxythymidine monophosphate. [[Methotrexate]] and other [[folic acid antagonist]]s used as chemotherapeutic drugs act by inhibiting this enzyme. Also known as [[dihydrofolate dehydrogenase]], [[dihydrofolate reductase]] and [[folic acid reductase]]; differs from [[methylenetetrahydrofolate reductase]] <noinclude>{{DefMeSH}}</noinclude> | ||
Latest revision as of 14:25, 27 May 2010
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Tetrahydrofolate dehydrogenase [r]:
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihydrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. Also known as dihydrofolate dehydrogenase, dihydrofolate reductase and folic acid reductase; differs from methylenetetrahydrofolate reductase
This definition is at least in part based on: Anonymous (2024), Tetrahydrofolate dehydrogenase (English). Medical Subject Headings. U.S. National Library of Medicine.