Mixed connective tissue disease: Difference between revisions

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imported>Howard C. Berkowitz
(New page: {{seealso|Scleroderma}} Now understood to be a distinct disease, '''mixed connective tissue disease (MCTD)''' is variously considered an overlap between systemic lupus erythematosus, scler...)
 
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{{seealso|Scleroderma}}
{{seealso|Scleroderma}}
Now understood to be a distinct disease, '''mixed connective tissue disease (MCTD)''' is variously considered an overlap between systemic lupus erythematosus, scleroderma, and polymyositis; a specific subest of  [[scleroderma]] with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity.
Now understood to be a distinct disease, '''mixed connective tissue disease (MCTD)''' is variously considered an overlap (i.e., '''overlap connective tissue disease''') between [[systemic lupus erythematosus]] (SLE), [[scleroderma]], and [[polymyositis]]; a specific subset of  [[scleroderma]] with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity.


Most patients with MCTD have [[autoantibody|autoantibodies]] to [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP),
Most patients with MCTD have [[autoantibody|autoantibodies]] characteristic of scleroderma, such as [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP), and have clinical [[Raynaud's phenomenon]].

Revision as of 07:51, 31 July 2010

See also: Scleroderma

Now understood to be a distinct disease, mixed connective tissue disease (MCTD) is variously considered an overlap (i.e., overlap connective tissue disease) between systemic lupus erythematosus (SLE), scleroderma, and polymyositis; a specific subset of scleroderma with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity.

Most patients with MCTD have autoantibodies characteristic of scleroderma, such as U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP), and have clinical Raynaud's phenomenon.