Mixed connective tissue disease: Difference between revisions
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{{seealso|Scleroderma}} | {{seealso|Scleroderma}} | ||
First described in 1972, <ref>{{citation | |||
| title = Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). | |||
| journal = Am J Med | |||
| year= 1972 | volume = 52 |issue =2 | pages 148-59 3) | |||
| author = Sharp GC; Irvin WS; Tan EM; Gould RG; Holman HR}}</ref> often called distinct [[rheumatology|rheumatologic]] disease, '''mixed connective tissue disease (MCTD)''' is variously considered an overlap (i.e., '''overlap connective tissue disease''') between [[systemic lupus erythematosus]] (SLE), [[scleroderma]], and [[polymyositis]]; a specific subset of [[scleroderma]] with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity. <ref>{{citation | |||
| contribution = Chapter 35: Clinical features of systemic sclerosis | | contribution = Chapter 35: Clinical features of systemic sclerosis | ||
| author = Fredrick M Wigley and Laura K Hummers | | author = Fredrick M Wigley and Laura K Hummers | ||
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| publisher = Mosby | | publisher = Mosby | ||
| year = 2004 | | year = 2004 | ||
| isbn = 03230299396}}</ref> In [[Medical Subject Headings]], it is termed "A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence." <ref>{{MeSH}}</ref> | | isbn = 03230299396}}, p. 450</ref> In [[Medical Subject Headings]], it is termed "A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence." <ref>{{MeSH}}</ref> | ||
Most patients with MCTD have [[autoantibody|autoantibodies]] characteristic of scleroderma, such as [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP), and have clinical [[Raynaud's phenomenon]]. | Most patients with MCTD have [[autoantibody|autoantibodies]] characteristic of scleroderma, such as [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP), and have clinical [[Raynaud's phenomenon]]. | ||
==References== | ==References== | ||
{{reflist}} | {{reflist|2}} | ||
Revision as of 08:32, 31 July 2010
- See also: Scleroderma
First described in 1972, [1] often called distinct rheumatologic disease, mixed connective tissue disease (MCTD) is variously considered an overlap (i.e., overlap connective tissue disease) between systemic lupus erythematosus (SLE), scleroderma, and polymyositis; a specific subset of scleroderma with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity. [2] In Medical Subject Headings, it is termed "A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence." [3]
Most patients with MCTD have autoantibodies characteristic of scleroderma, such as U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP), and have clinical Raynaud's phenomenon.
References
- ↑ Sharp GC; Irvin WS; Tan EM; Gould RG; Holman HR (1972), "Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).", Am J Med 52 (2)
- ↑ Fredrick M Wigley and Laura K Hummers (2004), Chapter 35: Clinical features of systemic sclerosis, Practical Rheumatology (Third ed.), Mosby, ISBN 03230299396, p. 450
- ↑ Anonymous (2024), Mixed connective tissue disease (English). Medical Subject Headings. U.S. National Library of Medicine.