Corticosteroid: Difference between revisions
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'''Corticosteroids''', also called adrenal cortex hormones, are mainly produced by the adrenal cortex. | '''Corticosteroids''', also called adrenal cortex hormones, are [[steroids]] mainly produced by the adrenal cortex. | ||
==Classification== | ==Classification== | ||
| Line 9: | Line 9: | ||
===Glucocorticoids=== | ===Glucocorticoids=== | ||
[[Glucocorticoid]]s | [[Glucocorticoid]]s affect carbohydrate metabolism and inflammation are mainly produced in the zona fasciculata of the adrenal cortex. The naturally occurring glucocorticoids include hydrocortisone (also called cortisol).<ref name="pmid16236742">{{cite journal |author=Rhen T, Cidlowski JA |title=Antiinflammatory action of glucocorticoids--new mechanisms for old drugs |journal=N. Engl. J. Med. |volume=353 |issue=16 |pages=1711–23 |year=2005 |pmid=16236742 |doi=10.1056/NEJMra050541}}</ref> The normal adult secretes 10 to 20 mg of cortisol per day.<ref name="isbn0-07-145153-6">{{cite book |author=Katzung, Bertram G. |title=Basic and clinical pharmacology |publisher=McGraw-Hill Medical Publishing Division |location=New York |year=2006 |pages= |isbn=0-07-145153-6 |oclc= |doi=}}</ref> | ||
===Hydroxycorticosteroids=== | ===Hydroxycorticosteroids=== | ||
The hydroxycorticosteroids are mostly the [[mineralocorticoid]]s and are mainly produced in the zona glomerulosa layer (the outermost layer of the adrenal gland) of the adrenal cortex.<ref name="pmid8015573">{{cite journal |author=White PC |title=Disorders of aldosterone biosynthesis and action |journal=N. Engl. J. Med. |volume=331 |issue=4 |pages=250–8 |year=1994 |pmid=8015573 |doi=}}</ref> The naturally occurring mineralocorticoids include aldosterone and deoxycorticosterone. | The hydroxycorticosteroids are mostly the [[mineralocorticoid]]s and are mainly produced in the zona glomerulosa layer (the outermost layer of the adrenal gland) of the adrenal cortex.<ref name="pmid8015573">{{cite journal |author=White PC |title=Disorders of aldosterone biosynthesis and action |journal=N. Engl. J. Med. |volume=331 |issue=4 |pages=250–8 |year=1994 |pmid=8015573 |doi=}}</ref> The naturally occurring mineralocorticoids include [[aldosterone]] and [[deoxycorticosterone]]. | ||
{| class="wikitable" align="right" sortable | |||
{| class="wikitable" align=" | |||
|+ Relative potencies of the corticosteroids | |+ Relative potencies of the corticosteroids | ||
! !! Anti-inflammatory !! Salt-retention | ! !! Anti-inflammatory !! Salt-retention | ||
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| colspan="3" | Adapted from [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cmed.table.12860 Cancer Medicine] and [http://www.uspharmacist.com/NewLook/CE/glucocort/lesson.htm US Pharmacist] | | colspan="3" | Adapted from [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=cmed.table.12860 Cancer Medicine] and [http://www.uspharmacist.com/NewLook/CE/glucocort/lesson.htm US Pharmacist] | ||
|} | |} | ||
==Therapeutic uses== | |||
===Infectious diseases=== | |||
Corticosteroids are beneficial in treated selected infections<ref name="pmid18504331">{{cite journal |author=McGee S, Hirschmann J |title=Use of corticosteroids in treating infectious diseases |journal=Arch. Intern. Med. |volume=168 |issue=10 |pages=1034–46 |year=2008 |month=May |pmid=18504331 |doi=10.1001/archinte.168.10.1034 |url=http://archinte.ama-assn.org/cgi/pmidlookup?view=long&pmid=18504331 |issn=}}</ref> | |||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 11:00, 2 August 2024
Corticosteroids, also called adrenal cortex hormones, are steroids mainly produced by the adrenal cortex.
Classification
There are three major groups of corticosteroids.[1]
17-Ketosteroids
The 17-Ketosteroids are the sex steroids and are mainly produced in the zona reticularis layer (the innermost layer of the adrenal gland) of the adrenal cortex.
Glucocorticoids
Glucocorticoids affect carbohydrate metabolism and inflammation are mainly produced in the zona fasciculata of the adrenal cortex. The naturally occurring glucocorticoids include hydrocortisone (also called cortisol).[2] The normal adult secretes 10 to 20 mg of cortisol per day.[3]
Hydroxycorticosteroids
The hydroxycorticosteroids are mostly the mineralocorticoids and are mainly produced in the zona glomerulosa layer (the outermost layer of the adrenal gland) of the adrenal cortex.[4] The naturally occurring mineralocorticoids include aldosterone and deoxycorticosterone.
| Anti-inflammatory | Salt-retention | |
|---|---|---|
| Hydrocortisone | 1 | 1 |
| Cortisone | 0.8 | 0.8 |
| Prednisone | 4 | 0.8 |
| Prednisolone | 4 | 0.8 |
| Triamcinolone | 5 | 0 |
| Prednisolone | 5 | 0 |
| Methylprednisolone | 5 | 0 |
| Dexamethasone | 30 | 0 |
| Fludocortisone | 10 | 250 |
| Adapted from Cancer Medicine and US Pharmacist | ||
Therapeutic uses
Infectious diseases
Corticosteroids are beneficial in treated selected infections[5]
References
- ↑ National Library of Medicine. Adrenal Cortex Hormones. Retrieved on 2007-11-27.
- ↑ Rhen T, Cidlowski JA (2005). "Antiinflammatory action of glucocorticoids--new mechanisms for old drugs". N. Engl. J. Med. 353 (16): 1711–23. DOI:10.1056/NEJMra050541. PMID 16236742. Research Blogging.
- ↑ Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division. ISBN 0-07-145153-6.
- ↑ White PC (1994). "Disorders of aldosterone biosynthesis and action". N. Engl. J. Med. 331 (4): 250–8. PMID 8015573. [e]
- ↑ McGee S, Hirschmann J (May 2008). "Use of corticosteroids in treating infectious diseases". Arch. Intern. Med. 168 (10): 1034–46. DOI:10.1001/archinte.168.10.1034. PMID 18504331. Research Blogging.