imported>Andrew Su |
imported>Meg Taylor |
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| {{subpages2}} | | <noinclude>{{subpages}}</noinclude> |
| {{Protein2
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| | image = APP_structure.jpg
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| | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aap.
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| | PDB = {{PDB2|1aap}}, {{PDB2|1amb}}, {{PDB2|1amc}}, {{PDB2|1aml}}, {{PDB2|1ba4}}, {{PDB2|1ba6}}, {{PDB2|1brc}}, {{PDB2|1ca0}}, {{PDB2|1iyt}}, {{PDB2|1mwp}}, {{PDB2|1owt}}, {{PDB2|1rw6}}, {{PDB2|1taw}}, {{PDB2|1tkn}}, {{PDB2|1z0q}}, {{PDB2|1zjd}}, {{PDB2|2beg}}, {{PDB2|2fjz}}, {{PDB2|2fk1}}, {{PDB2|2fk2}}, {{PDB2|2fk3}}, {{PDB2|2fkl}}, {{PDB2|2fma}}, {{PDB2|2g47}}
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| | Name = Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
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| | HGNCid = 620
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| | Symbol = APP
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| | AltSymbols =; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2
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| | OMIM = 104760
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| | ECnumber =
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| | Homologene = 56379
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| | MGIid = 88059
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| | GeneAtlas_image =
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| <!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
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| | DateOfBotUpdate = 20:15, 15 August 2007 (UTC)
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| | Function = {{GO|id=GO:0000085 |text = G2 phase of mitotic cell cycle}} {{GO|id=GO:0001967 |text = suckling behavior}} {{GO|id=GO:0003677 |text = DNA binding}} {{GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GO|id=GO:0005488 |text = binding}} {{GO|id=GO:0005506 |text = iron ion binding}} {{GO|id=GO:0005507 |text = copper ion binding}} {{GO|id=GO:0005576 |text = extracellular region}} {{GO|id=GO:0005624 |text = membrane fraction}} {{GO|id=GO:0005737 |text = cytoplasm}} {{GO|id=GO:0005794 |text = Golgi apparatus}} {{GO|id=GO:0005887 |text = integral to plasma membrane}} {{GO|id=GO:0005905 |text = coated pit}} {{GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GO|id=GO:0006878 |text = cellular copper ion homeostasis}} {{GO|id=GO:0006897 |text = endocytosis}} {{GO|id=GO:0006915 |text = apoptosis}} {{GO|id=GO:0007155 |text = cell adhesion}} {{GO|id=GO:0007219 |text = Notch signaling pathway}} {{GO|id=GO:0007409 |text = axonogenesis}} {{GO|id=GO:0007617 |text = mating behavior}} {{GO|id=GO:0008088 |text = axon cargo transport}} {{GO|id=GO:0008201 |text = heparin binding}} {{GO|id=GO:0008270 |text = zinc ion binding}} {{GO|id=GO:0008344 |text = adult locomotory behavior}} {{GO|id=GO:0008542 |text = visual learning}} {{GO|id=GO:0009986 |text = cell surface}} {{GO|id=GO:0016020 |text = membrane}} {{GO|id=GO:0016021 |text = integral to membrane}} {{GO|id=GO:0016199 |text = axon midline choice point recognition}} {{GO|id=GO:0016322 |text = neuron remodeling}} {{GO|id=GO:0016358 |text = dendrite development}} {{GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}} {{GO|id=GO:0030424 |text = axon}} {{GO|id=GO:0030900 |text = forebrain development}} {{GO|id=GO:0031410 |text = cytoplasmic vesicle}} {{GO|id=GO:0031594 |text = neuromuscular junction}} {{GO|id=GO:0035253 |text = ciliary rootlet}} {{GO|id=GO:0040014 |text = regulation of body size}} {{GO|id=GO:0042802 |text = identical protein binding}} {{GO|id=GO:0045177 |text = apical part of cell}} {{GO|id=GO:0045931 |text = positive regulation of progression through mitotic cell cycle}} {{GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GO|id=GO:0046872 |text = metal ion binding}} {{GO|id=GO:0048471 |text = perinuclear region of cytoplasm}} {{GO|id=GO:0048669 |text = collateral sprouting in the absence of injury}} {{GO|id=GO:0050803 |text = regulation of synapse structure and activity}} {{GO|id=GO:0050885 |text = regulation of balance}} {{GO|id=GO:0050905 |text = neuromuscular process}} {{GO|id=GO:0051124 |text = synaptic growth at neuromuscular junction}} {{GO|id=GO:0051233 |text = spindle midzone}} {{GO|id=GO:0051563 |text = smooth endoplasmic reticulum calcium ion homeostasis}}
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| | Orthologs = {{Ortholog_box
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| | Hs_EntrezGene = 351
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| | Hs_Ensembl = ENSG00000142192
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| | Hs_RefseqProtein = NP_000475
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| | Hs_RefseqmRNA = NM_000484
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| | Hs_GenLoc_db =
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| | Hs_GenLoc_chr = 21
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| | Hs_GenLoc_start = 26174733
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| | Hs_GenLoc_end = 26465003
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| | Hs_Uniprot = P05067
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| | Mm_EntrezGene = 11820
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| | Mm_Ensembl = ENSMUSG00000022892
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| | Mm_RefseqmRNA = NM_007471
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| | Mm_RefseqProtein = NP_031497
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| | Mm_GenLoc_db =
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| | Mm_GenLoc_chr = 16
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| | Mm_GenLoc_start = 84837873
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| | Mm_GenLoc_end = 85057149
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| | Mm_Uniprot =
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| }}
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| }}
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| Two representative images showing 3D structure:
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| [[Image:APP_structure_2fk1.jpg]]
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| [[Image:APP_structure_1z0q.jpg]]
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