imported>Robert Badgett |
imported>Robert Badgett |
Line 1: |
Line 1: |
| {{subpages}} | | {{subpages}} |
| {{editintro}} | | {{editintro}} |
| ==Adverse effects==
| | #redirect [[Anticoagulant]] |
| Patients aged 80 years or more may be especially susceptible to bleeding complications with a rate of 13 bleeds per 100 person-years.<ref name="pmid17515465">{{cite journal |author=Hylek EM, Evans-Molina C, Shea C, Henault LE, Regan S |title=Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation |journal=Circulation |volume=115 |issue=21 |pages=2689-96 |year=2007 |pmid=17515465 |doi=10.1161/CIRCULATIONAHA.106.653048}}PMID 17515465</ref>
| |
| | |
| Patients with cancer are more likely to have bleeding complications, especially if they have Stage III (regionally extensive) or IV (metastatic) cancer.<ref name="pmid12393647">{{cite journal |author=Prandoni P, Lensing AW, Piccioli A, ''et al'' |title=Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis |journal=Blood |volume=100 |issue=10 |pages=3484–8 |year=2002 |pmid=12393647 |doi=10.1182/blood-2002-01-0108}}</ref> Regardless of the extent of cancer, the risk of bleeding was less than the risk of recurrent [[embolism and thromboembolism]]:
| |
| | |
| | |
| | |
| {| class="wikitable"
| |
| |+ Rates of major bleeding and recurrent [[embolism and thromboembolism]] (VTE)
| |
| ! colspan="2" rowspan="2" | !! rowspan="2"| No cancer !! colspan="3" | Cancer
| |
| |-
| |
| ! Stage I or II !! Stage III !! Stage IV
| |
| |-
| |
| | rowspan="2"| '''Major<br>bleeding''' || Events per<br>100 patient-years ||align="center"| 8.6 || align="center"|3.4 ||align="center"| 19.1 ||align="center"| 42.8
| |
| |-
| |
| | Hazard ratio ||align="center"| 1 ||align="center"| 0.5 ||align="center"| 2.15 ||align="center"| 4.8
| |
| |-
| |
| | rowspan="2"| '''Recurrent<br>VTE''' || Events per<br>100 patient-years ||align="center"| 12.8 ||align="center"| 14.5 ||align="center"| 44.1 ||align="center"| 54.1
| |
| |-
| |
| | Hazard ratio ||align="center"| 1 ||align="center"| 1.9 ||align="center"| 5.3 ||align="center"| 4.6
| |
| |-
| |
| | colspan="6" align="right"| Adapted from Table 3 of Prandoni et al.<ref name="pmid12393647"/>
| |
| |}
| |
|
| |
|
| ==References== | | ==References== |