Echinacea: Difference between revisions
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Within medicine in the United States and Britain, there is no role for echinacea according to most [[systematic review]]s in treating or preventing the [[common cold]]<ref name="pmid16437427">{{cite journal |author=Linde K, Barrett B, Wölkart K, Bauer R, Melchart D |title=Echinacea for preventing and treating the common cold |journal=Cochrane Database Syst Rev |volume= |issue=1 |pages=CD000530 |year=2006 |pmid=16437427 |doi=10.1002/14651858.CD000530.pub2|quote=some evidence that preparations based on the aerial parts of Echinacea purpurea might be effective for the early treatment of colds in adults but results are not fully consistent}}</ref><ref name="pmid16973075">{{cite journal |author=Arroll B |title=Common cold |journal=Clin Evid |volume= |issue=15 |pages=2006–14 |year=2006 |pmid=16973075 |doi=|url=http://clinicalevidence.bmj.com/ceweb/conditions/rda/1510/1510.jsp}}</ref> of [[randomized controlled trial]]s.<ref name="pmid15197051">{{cite journal |author=Yale SH, Liu K |title=Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial |journal=Arch. Intern. Med. |volume=164 |issue=11 |pages=1237–41 |year=2004 |pmid=15197051 |doi=10.1001/archinte.164.11.1237}}</ref><ref name="pmid12484708">{{cite journal |author=Barrett BP, Brown RL, Locken K, Maberry R, Bobula JA, D'Alessio D |title=Treatment of the common cold with unrefined echinacea. A randomized, double-blind, placebo-controlled trial |journal=Ann. Intern. Med. |volume=137 |issue=12 |pages=939–46 |year=2002 |pmid=12484708 |doi=|url=http://www.annals.org/cgi/content/full/137/12/939}}</ref> An additional randomized controlled trial found no benefit in experimentally induced rhinovirus infection.<ref name="pmid16049208">{{cite journal |author=Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD |title=An evaluation of Echinacea angustifolia in experimental rhinovirus infections |journal=N. Engl. J. Med. |volume=353 |issue=4 |pages=341–8 |year=2005 |pmid=16049208 |doi=10.1056/NEJMoa044441|url=http://content.nejm.org/cgi/content/full/353/4/341}}</ref> A meta-analysis by the Cochrane Collaboration concluded there may be a role for the aerial parts of Echinacea purpurea that needs further study.<ref name="pmid16437427"/> | |||
More recently, a [[meta-analysis]] concluded that echinacea may help in both prevention and reducing duration.<ref name="pmid17597571">{{cite journal |author=Shah SA, Sander S, White CM, Rinaldi M, Coleman CI |title=Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis |journal=Lancet Infect Dis |volume=7 |issue=7 |pages=473–80 |year=2007 |pmid=17597571 |doi=10.1016/S1473-3099(07)70160-3}}</ref> This meta-analysis did not study the effect on the severity of cold symptoms. This is difficult to interpret as two of the best studies,<ref name="pmid12484708"/><ref name="pmid16049208"/> that used placebos designed to mimic the taste and texture of the echinacea, were both negative. In addition, this meta-analysis reported funnel plot asymmetry which notes its results may be affected by [[publication bias]] against negative studies. | More recently, a [[meta-analysis]] conducted in the U.S concluded that echinacea may help in both prevention and reducing duration.<ref name="pmid17597571">{{cite journal |author=Shah SA, Sander S, White CM, Rinaldi M, Coleman CI |title=Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis |journal=Lancet Infect Dis |volume=7 |issue=7 |pages=473–80 |year=2007 |pmid=17597571 |doi=10.1016/S1473-3099(07)70160-3}}</ref> This meta-analysis did not study the effect on the severity of cold symptoms. This is difficult to interpret as two of the best studies,<ref name="pmid12484708"/><ref name="pmid16049208"/> that used placebos designed to mimic the taste and texture of the echinacea, were both negative. In addition, this meta-analysis reported funnel plot asymmetry which notes its results may be affected by [[publication bias]] against negative studies. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 03:09, 4 February 2008
Echinacea, also called coneflower or rudbeckia purpurea, is a genus of nine perennial herbs used topically and internally. It contains echinacoside, glycosides; inulin; isobutyl amides, resin, and sesquiterpenes."[1] Its name is derived from the Greek echinos, meaning "hedgehog", because its prickly scales resemble the spines of an angered hedgehog. The plant has a long history of use as an herbal medicine, is popular today as such, and has been the subject of numerous scientific studies in these regards, with varied results.[2]
Botany
The echinacea genus is in the aster family.[3] The genus contains nine species including E. angustifolia (blacksamson echinacea) and E. purpurea (eastern purple coneflower). E. angustifolia grows in the central United States.[4] E. purpurea grows in the eastern United States except for northern New England.[5]
Traditional uses
Archaeological digs suggest that certain Native Americans used echinacea for at least 400 years as a sort of "cure all", and for infections and wounds. Elsewhere, echinacea has been used to treat scarlet fever, syphilis, malaria, blood poisoning, and diphtheria. In the United States, it was especially popular during the 18th and 19th centuries, although usages declined after the introduction of antibiotics. In Germany, echinacea became increasingly popular through the 20th century.[2] Of the nine species, Echinacea angustifolia, Echinacea pallida, and Echinacea purpurea are the most commonly ones used medicinally.[2]
Phytochemicals
The chemicals contained in the upper part of the plant and its root differ considerably. The above-ground parts of the plant are known to contain high amounts of polysaccharides, which have been shown to trigger immune system activity, while the roots contain high concentrations of volatile oils (odorous compounds).[2]
Role in health care
German scientists have conducted the majority of research on echinacea. The above-ground parts of Echinacea purpurea are approved by the German government to treat colds, upper respiratory tract infections, urinary tract infections, and slow-healing wounds, while Echinacea pallida root is approved to treat flu-like infections.[2]
Within medicine in the United States and Britain, there is no role for echinacea according to most systematic reviews in treating or preventing the common cold[6][7] of randomized controlled trials.[8][9] An additional randomized controlled trial found no benefit in experimentally induced rhinovirus infection.[10] A meta-analysis by the Cochrane Collaboration concluded there may be a role for the aerial parts of Echinacea purpurea that needs further study.[6]
More recently, a meta-analysis conducted in the U.S concluded that echinacea may help in both prevention and reducing duration.[11] This meta-analysis did not study the effect on the severity of cold symptoms. This is difficult to interpret as two of the best studies,[9][10] that used placebos designed to mimic the taste and texture of the echinacea, were both negative. In addition, this meta-analysis reported funnel plot asymmetry which notes its results may be affected by publication bias against negative studies.
References
- ↑ Anonymous (2024), Echinacea (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 2.2 2.3 2.4 University of Maryland Medical Center. Echinacea. USDA Plants. Retrieved on 2008-02-03. Cite error: Invalid
<ref>tag; name "UofM-ECHIN" defined multiple times with different content Cite error: Invalid<ref>tag; name "UofM-ECHIN" defined multiple times with different content Cite error: Invalid<ref>tag; name "UofM-ECHIN" defined multiple times with different content Cite error: Invalid<ref>tag; name "UofM-ECHIN" defined multiple times with different content - ↑ USDA. Classification for Kingdom Plantae Down to Genus Echinacea Moench. USDA Plants. Retrieved on 2008-02-03.
- ↑ USDA. PLANTS Profile for Echinacea angustifolia (blacksamson echinacea). USDA PLANTS. Retrieved on 2008-02-03.
- ↑ USDA. PLANTS Profile for Echinacea purpurea (eastern purple coneflower). USDA PLANTS. Retrieved on 2008-02-03.
- ↑ 6.0 6.1 Linde K, Barrett B, Wölkart K, Bauer R, Melchart D (2006). "Echinacea for preventing and treating the common cold". Cochrane Database Syst Rev (1): CD000530. DOI:10.1002/14651858.CD000530.pub2. PMID 16437427. Research Blogging. “some evidence that preparations based on the aerial parts of Echinacea purpurea might be effective for the early treatment of colds in adults but results are not fully consistent”
- ↑ Arroll B (2006). "Common cold". Clin Evid (15): 2006–14. PMID 16973075. [e]
- ↑ Yale SH, Liu K (2004). "Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial". Arch. Intern. Med. 164 (11): 1237–41. DOI:10.1001/archinte.164.11.1237. PMID 15197051. Research Blogging.
- ↑ 9.0 9.1 Barrett BP, Brown RL, Locken K, Maberry R, Bobula JA, D'Alessio D (2002). "Treatment of the common cold with unrefined echinacea. A randomized, double-blind, placebo-controlled trial". Ann. Intern. Med. 137 (12): 939–46. PMID 12484708. [e]
- ↑ 10.0 10.1 Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD (2005). "An evaluation of Echinacea angustifolia in experimental rhinovirus infections". N. Engl. J. Med. 353 (4): 341–8. DOI:10.1056/NEJMoa044441. PMID 16049208. Research Blogging.
- ↑ Shah SA, Sander S, White CM, Rinaldi M, Coleman CI (2007). "Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis". Lancet Infect Dis 7 (7): 473–80. DOI:10.1016/S1473-3099(07)70160-3. PMID 17597571. Research Blogging.