Cell surface receptor: Difference between revisions
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'''Cell surface receptors''' are "proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands."<ref name="isbn0-8153-4105-9">{{cite book |author=Alberts, Bruce |authorlink= |editor= |others= |title=Molecular Biology of the Cell |edition= |language= |publisher=Other |location= |year=2007 |origyear= |pages= |quote= |isbn=0-8153-4105-9 |oclc= |doi= |url= |accessdate=}}</ref><ref>{{MeSH|Cell surface | '''Cell surface receptors''' are "proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands."<ref name="isbn0-8153-4105-9">{{cite book |author=Alberts, Bruce |authorlink= |editor= |others= |title=Molecular Biology of the Cell |edition= |language= |publisher=Other |location= |year=2007 |origyear= |pages= |quote= |isbn=0-8153-4105-9 |oclc= |doi= |url= |accessdate=}}</ref><ref>{{MeSH|Cell surface receptors}}</ref> Examples are [[neurotransmitter]]s and [[biogenic amine receptor]]s. | ||
==Classification== | ==Classification== | ||
Revision as of 12:12, 15 June 2008
Cell surface receptors are "proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands."[1][2] Examples are neurotransmitters and biogenic amine receptors.
Classification
Mechanistic classes include:[3]
- Protein-tyrosine kinase receptor
- Ion channel
- G-protein-coupled receptor
References
- ↑ Alberts, Bruce (2007). Molecular Biology of the Cell. Other. ISBN 0-8153-4105-9.
- ↑ Anonymous (2024), Cell surface receptors (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Katzung, Bertram G. (2006). Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division, 18. ISBN 0-07-145153-6.