Carotid intima-media thickness: Difference between revisions
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imported>Robert Badgett (New page: In medicine and cardiovascular disease, the '''carotid intima-media thickness''' (CIMT) is a surrogate outcome measure used in randomized controlled trials of the treatment of ...) |
imported>Howard C. Berkowitz No edit summary |
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In [[medicine]] and [[cardiovascular disease]], the '''carotid intima-media thickness''' (CIMT) is a surrogate outcome measure used in [[randomized controlled trial]]s of the treatment of [[atherosclerosis]].<ref name="pmid18376002">{{cite journal |author=Brown BG, Taylor AJ |title=Does ENHANCE diminish confidence in lowering LDL or in ezetimibe? |journal=N. Engl. J. Med. |volume=358 |issue=14 |pages=1504–7 |year=2008 |month=April |pmid=18376002 |doi=10.1056/NEJMe0801608 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=18376002&promo=ONFLNS19 |issn=}}</ref> It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."<ref name="pmid18376002"/> | {{subpages}} | ||
In [[medicine]] and [[cardiovascular disease]], the '''carotid intima-media thickness''' (CIMT), measuring the [[carotid artery]], is a surrogate outcome measure used in [[randomized controlled trial]]s of the treatment of [[atherosclerosis]].<ref name="pmid18376002">{{cite journal |author=Brown BG, Taylor AJ |title=Does ENHANCE diminish confidence in lowering LDL or in ezetimibe? |journal=N. Engl. J. Med. |volume=358 |issue=14 |pages=1504–7 |year=2008 |month=April |pmid=18376002 |doi=10.1056/NEJMe0801608 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=18376002&promo=ONFLNS19 |issn=}}</ref> It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."<ref name="pmid18376002"/> | |||
A [[meta-analysis]] concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."<ref name="pmid17277033">{{cite journal |author=Bots ML, Baldassarre D, Simon A, ''et al'' |title=Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? |journal=Eur. Heart J. |volume=28 |issue=4 |pages=398–406 |year=2007 |month=February |pmid=17277033 |doi=10.1093/eurheartj/ehl482 |url=http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17277033 |issn=}}</ref> | A [[meta-analysis]] concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."<ref name="pmid17277033">{{cite journal |author=Bots ML, Baldassarre D, Simon A, ''et al'' |title=Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? |journal=Eur. Heart J. |volume=28 |issue=4 |pages=398–406 |year=2007 |month=February |pmid=17277033 |doi=10.1093/eurheartj/ehl482 |url=http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17277033 |issn=}}</ref> | ||
Revision as of 23:41, 12 February 2009
In medicine and cardiovascular disease, the carotid intima-media thickness (CIMT), measuring the carotid artery, is a surrogate outcome measure used in randomized controlled trials of the treatment of atherosclerosis.[1] It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."[1]
A meta-analysis concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."[2]
References
- ↑ 1.0 1.1 Brown BG, Taylor AJ (April 2008). "Does ENHANCE diminish confidence in lowering LDL or in ezetimibe?". N. Engl. J. Med. 358 (14): 1504–7. DOI:10.1056/NEJMe0801608. PMID 18376002. Research Blogging.
- ↑ Bots ML, Baldassarre D, Simon A, et al (February 2007). "Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?". Eur. Heart J. 28 (4): 398–406. DOI:10.1093/eurheartj/ehl482. PMID 17277033. Research Blogging.