Diabetic ketoacidosis: Difference between revisions
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| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=16520476 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=16520476 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | ||
DKA is often secondary to infection or other comorbidity, which must be diagnosed and treated.<ref name="pmid20048266">{{cite journal| author=Wilson JF| title=In clinic. Diabetic ketoacidosis. | journal=Ann Intern Med | year= 2010 | volume= 152 | issue= 1 | pages= ITC1 | pmid=20048266 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=20048266 | doi=10.1059/0003-4819-152-1-201001050-01001 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref><ref name=eMedicine>{{citation | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=20048266 | doi=10.1059/0003-4819-152-1-201001050-01001 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref><ref name=eMedicine>{{citation | ||
| url = http://emedicine.medscape.com/article/766275-print | | url = http://emedicine.medscape.com/article/766275-print | ||
| journal = eMedicine | date = February 12, 2008 | author = Rucker DW | | journal = eMedicine | date = February 12, 2008 | author = Rucker DW | ||
| title = Diabetic ketoacidosis | | title = Diabetic ketoacidosis | ||
}}</ref>As | }}</ref> | ||
==Diagnosis== | |||
The blood glucose is usually above 250 mg/dl.<ref name="pmid19564476">{{cite journal| author=Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN| title=Hyperglycemic crises in adult patients with diabetes. | journal=Diabetes Care | year= 2009 | volume= 32 | issue= 7 | pages= 1335-43 | pmid=19564476 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=19564476 | doi=10.2337/dc09-9032 | pmc=PMC2699725 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | |||
==Treatment== | |||
Treatment begins with fluid replacement; insulin is not started immediately. As DKA is treated, DKA converts from a high anion gap metabolic [[acidosis]] to a normal anion gap metabolic [[acidosis]] due to "excretion of ketone anions in the urine"<ref name="pmid102229">{{cite journal |author=Oh MS, Carroll HJ, Goldstein DA, Fein IA |title=Hyperchloremic acidosis during the recovery phase of diabetic ketosis |journal=Ann. Intern. Med. |volume=89 |issue=6 |pages=925–7 |year=1978 |month=December |pmid=102229 |doi= |url= |issn=}}</ref>, especially if excreted with sodium or potassium cations. | |||
==References== | ==References== | ||
<references/> | <references/> |
Revision as of 23:31, 18 January 2010
In medicine, diabetic ketoacidosis (DKA) is a type of metabolic acidosis that is a "life-threatening complication of diabetes mellitus, primarily of Type 1 Diabetes Mellitus with severe insulin deficiency and hyperglycemia. It is characterized by excessive lipolysis, oxidation of fatty acids, production of ketone bodies, a sweet smell to the breath (ketosis;) dehydration; and depressed consciousness leading to coma.[1] can also occur with Diabetes mellitus type 2[2]
DKA is often secondary to infection or other comorbidity, which must be diagnosed and treated.[3][4]
Diagnosis
The blood glucose is usually above 250 mg/dl.[5]
Treatment
Treatment begins with fluid replacement; insulin is not started immediately. As DKA is treated, DKA converts from a high anion gap metabolic acidosis to a normal anion gap metabolic acidosis due to "excretion of ketone anions in the urine"[6], especially if excreted with sodium or potassium cations.
References
- ↑ Anonymous (2024), Diabetic ketoacidosis (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Umpierrez GE, Smiley D, Kitabchi AE (2006). "Narrative review: ketosis-prone type 2 diabetes mellitus.". Ann Intern Med 144 (5): 350-7. PMID 16520476.
- ↑ Wilson JF (2010). "In clinic. Diabetic ketoacidosis.". Ann Intern Med 152 (1): ITC1. DOI:10.1059/0003-4819-152-1-201001050-01001. PMID 20048266. Research Blogging.
- ↑ Rucker DW (February 12, 2008), "Diabetic ketoacidosis", eMedicine
- ↑ Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (2009). "Hyperglycemic crises in adult patients with diabetes.". Diabetes Care 32 (7): 1335-43. DOI:10.2337/dc09-9032. PMID 19564476. PMC PMC2699725. Research Blogging.
- ↑ Oh MS, Carroll HJ, Goldstein DA, Fein IA (December 1978). "Hyperchloremic acidosis during the recovery phase of diabetic ketosis". Ann. Intern. Med. 89 (6): 925–7. PMID 102229. [e]