Publication bias: Difference between revisions
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Publication bias is defined as "the influence of study results on the chances of publication [in [[academic journal]]s] and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?term=publication+bias |title=Publication bias |accessdate=2007-12-17 |author=National Library of Medicine |authorlink= |coauthors= |date= |format= |work= |publisher= |pages= |language= |archiveurl= |archivedate= |quote=}}</ref> Publication bias has been documented to occur<ref name="pmid1727960">{{cite journal |author=Dickersin K, Min YI, Meinert CL |title=Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards |journal=JAMA |volume=267 |issue=3 |pages=374–8 |year=1992 |pmid=1727960 |doi=}}</ref>. | {{subpages}} | ||
'''Publication bias''' is defined as "the influence of study results on the chances of publication [in [[academic journal]]s] and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc."<ref name="title">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?term=publication+bias |title=Publication bias |accessdate=2007-12-17 |author=National Library of Medicine |authorlink= |coauthors= |date= |format= |work= |publisher= |pages= |language= |archiveurl= |archivedate= |quote=}}</ref> Publication bias has been documented to occur<ref name="pmid1727960">{{cite journal |author=Dickersin K, Min YI, Meinert CL |title=Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards |journal=JAMA |volume=267 |issue=3 |pages=374–8 |year=1992 |pmid=1727960 |doi=}}</ref>. | |||
Publication bias may be due to authors not submitting negative studies for publication.<ref name="pmid12876092">{{cite journal |author=Krzyzanowska MK, Pintilie M, Tannock IF |title=Factors associated with failure to publish large randomized trials presented at an oncology meeting |journal=JAMA |volume=290 |issue=4 |pages=495–501 |year=2003 |pmid=12876092 |doi=10.1001/jama.290.4.495}}</ref> This may especially be true of studies authored by industries with conflicts of interest.<ref name="pmid12775615">{{cite journal |author=Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B |title=Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications |journal=BMJ |volume=326 |issue=7400 |pages=1171–3 |year=2003 |pmid=12775615 |doi=10.1136/bmj.326.7400.1171}}</ref> | Publication bias may be due to authors not submitting negative studies for publication.<ref name="pmid12876092">{{cite journal |author=Krzyzanowska MK, Pintilie M, Tannock IF |title=Factors associated with failure to publish large randomized trials presented at an oncology meeting |journal=JAMA |volume=290 |issue=4 |pages=495–501 |year=2003 |pmid=12876092 |doi=10.1001/jama.290.4.495}}</ref> This may especially be true of studies authored by industries with conflicts of interest.<ref name="pmid12775615">{{cite journal |author=Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B |title=Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications |journal=BMJ |volume=326 |issue=7400 |pages=1171–3 |year=2003 |pmid=12775615 |doi=10.1136/bmj.326.7400.1171}}</ref> | ||
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Revision as of 22:39, 23 December 2007
Publication bias is defined as "the influence of study results on the chances of publication [in academic journals] and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc."[1] Publication bias has been documented to occur[2].
Publication bias may be due to authors not submitting negative studies for publication.[3] This may especially be true of studies authored by industries with conflicts of interest.[4]
An example of probable publication bias is in the studies of glucosamine and chondroitin for treatment of osteoarthritis. In an initial meta-analysis, the authors noted evidence of publication bias during examination of the results.[5] A subsequent large randomized controlled trial[6] and meta-analyses including the large trial were negative[7][8].
Meta-analysis
Publication bias is a major threat to the validity of meta-analysis. Publication bias against negative studies may threaten the validity of meta-analyses that are positive and all the studies included within the meta-analysis are small.[9][10]
References
- ↑ National Library of Medicine. Publication bias. Retrieved on 2007-12-17.
- ↑ Dickersin K, Min YI, Meinert CL (1992). "Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards". JAMA 267 (3): 374–8. PMID 1727960. [e]
- ↑ Krzyzanowska MK, Pintilie M, Tannock IF (2003). "Factors associated with failure to publish large randomized trials presented at an oncology meeting". JAMA 290 (4): 495–501. DOI:10.1001/jama.290.4.495. PMID 12876092. Research Blogging.
- ↑ Melander H, Ahlqvist-Rastad J, Meijer G, Beermann B (2003). "Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications". BMJ 326 (7400): 1171–3. DOI:10.1136/bmj.326.7400.1171. PMID 12775615. Research Blogging.
- ↑ McAlindon TE, LaValley MP, Gulin JP, Felson DT (2000). "Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis". JAMA 283 (11): 1469–75. PMID 10732937. [e]
- ↑ Clegg DO, Reda DJ, Harris CL, et al (2006). "Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis". N. Engl. J. Med. 354 (8): 795–808. DOI:10.1056/NEJMoa052771. PMID 16495392. Research Blogging.
- ↑ Vlad SC, LaValley MP, McAlindon TE, Felson DT (2007). "Glucosamine for pain in osteoarthritis: why do trial results differ?". Arthritis Rheum. 56 (7): 2267–77. DOI:10.1002/art.22728. PMID 17599746. Research Blogging.
- ↑ Reichenbach S, Sterchi R, Scherer M, et al (2007). "Meta-analysis: chondroitin for osteoarthritis of the knee or hip". Ann. Intern. Med. 146 (8): 580–90. PMID 17438317. [e]
- ↑ Sutton AJ, Duval SJ, Tweedie RL, Abrams KR, Jones DR (2000). "Empirical assessment of effect of publication bias on meta-analyses". BMJ 320 (7249): 1574–7. PMID 10845965. [e]
- ↑ Egger M, Davey Smith G, Schneider M, Minder C (1997). "Bias in meta-analysis detected by a simple, graphical test". BMJ 315 (7109): 629–34. PMID 9310563. [e]