Benign prostatic hyperplasia: Difference between revisions
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===Medications=== | ===Medications=== | ||
* Alpha | * [[Alpha adrenergic blocker]]s can reduce the symptoms. Side effects may include headaches, dizziness, or feeling lightheaded or tired. | ||
* | * [[Testosterone 5-alpha-reductase]] inhibitors such as [[finasteride]] (Proscar®) can lower the amount of the male hormone (testosterone) in the body. The result is that the prostate shrinks and urinary problems get better. Side effects can include less interest in sex and problems with erection or ejaculation. | ||
* Saw palmetto plant extract (''Serenoa repens''). Despite initial positive reports<ref name="pmid9820264">{{cite journal |author=Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J, Mulrow C |title=Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review |journal=JAMA |volume=280 |issue=18 |pages=1604–9 |year=1998 |pmid=9820264 |doi=}}</ref>, a more recent [[randomized controlled trial]] found no benefit.<ref name="pmid16467543">{{cite journal |author=Bent S, Kane C, Shinohara K, ''et al'' |title=Saw palmetto for benign prostatic hyperplasia |journal=N. Engl. J. Med. |volume=354 |issue=6 |pages=557–66 |year=2006 |pmid=16467543 |doi=10.1056/NEJMoa053085}}</ref> | * Saw palmetto plant extract (''Serenoa repens''). Despite initial positive reports<ref name="pmid9820264">{{cite journal |author=Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J, Mulrow C |title=Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review |journal=JAMA |volume=280 |issue=18 |pages=1604–9 |year=1998 |pmid=9820264 |doi=}}</ref>, a more recent [[randomized controlled trial]] found no benefit.<ref name="pmid16467543">{{cite journal |author=Bent S, Kane C, Shinohara K, ''et al'' |title=Saw palmetto for benign prostatic hyperplasia |journal=N. Engl. J. Med. |volume=354 |issue=6 |pages=557–66 |year=2006 |pmid=16467543 |doi=10.1056/NEJMoa053085}}</ref> | ||
* If symptoms of urge and [[overactive urinary bladder]] are present, an antimuscarinic [[cholinergic antagonist]] such as [[tolterodine]] can be combined with an [[alpha adrenergic blocker] such as [[tamsulosin]].<ref name="pmid17105794">{{cite journal| author=Kaplan SA, Roehrborn CG, Rovner ES, Carlsson M, Bavendam T, Guan Z| title=Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial. | journal=JAMA | year= 2006 | volume= 296 | issue= 19 | pages= 2319-28 | pmid=17105794 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17105794 | doi=10.1001/jama.296.19.2319 }} </ref> | |||
===Surgery=== | ===Surgery=== |
Revision as of 10:43, 18 March 2010
Benign prostatic hyperplasia, or BPH, is very common in older men. The prostate is enlarged, but it is not cancerous. Over time, an enlarged prostate may press against the urethra, making it hard to urinate.
Diagnosis
BPH may cause dribbling after urinating or a need to urinate often, especially at night. A doctor will do a rectal exam to check for BPH. And he may suggest having special x-rays or scans to check the urethra, prostate, and bladder.
The American Urological Association Urinary symptom score is a validated measure of severity of symptoms.[1]
American Urological Association Urinary symptom score: ASK THE FOLLOWING QUESTIONS: Over the past month:
ANSWER THE QUESTIONS AS FOLLOWS, POINTS ARE BELOW: Not at < 1 < than 1/2 About 1/2 > than 1/2 Almost all time in 5 the time the time the time always 0 1 2 3 4 5 Total Score: 0-7 mild 8-19 moderate 20-35 severe |
Treatment
If the symptoms are not too bad, the doctor may suggest "watchful waiting" before starting any treatment. This includes regular checkups. Treatment can start later on if symptoms get worse.
Medications
- Alpha adrenergic blockers can reduce the symptoms. Side effects may include headaches, dizziness, or feeling lightheaded or tired.
- Testosterone 5-alpha-reductase inhibitors such as finasteride (Proscar®) can lower the amount of the male hormone (testosterone) in the body. The result is that the prostate shrinks and urinary problems get better. Side effects can include less interest in sex and problems with erection or ejaculation.
- Saw palmetto plant extract (Serenoa repens). Despite initial positive reports[2], a more recent randomized controlled trial found no benefit.[3]
- If symptoms of urge and overactive urinary bladder are present, an antimuscarinic cholinergic antagonist such as tolterodine can be combined with an [[alpha adrenergic blocker] such as tamsulosin.[4]
Surgery
An operation can improve the flow of urine but it can also cause other problems. Usually, men have surgery only if medicine hasn’t worked. This surgery does not protect against prostate cancer. Regular check-ups are important after BPH surgery. There are three kinds of surgery:
- Transurethral resection of the prostate (TURP) is the most common type of surgery. The surgeon takes out part of the prostate through the urethra.
- Transurethral incision of the prostate (TUIP) may be used when the prostate is not too large. The doctor makes a few small cuts in the prostate near the opening of the bladder.
- Open surgery is used only when the prostate is very large. The doctor removes the prostate through a cut in the belly or behind the scrotum.
References
- ↑ Barry MJ, Fowler FJ, O'Leary MP, et al (November 1992). "The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association". J. Urol. 148 (5): 1549–57; discussion 1564. PMID 1279218. [e]
- ↑ Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J, Mulrow C (1998). "Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review". JAMA 280 (18): 1604–9. PMID 9820264. [e]
- ↑ Bent S, Kane C, Shinohara K, et al (2006). "Saw palmetto for benign prostatic hyperplasia". N. Engl. J. Med. 354 (6): 557–66. DOI:10.1056/NEJMoa053085. PMID 16467543. Research Blogging.
- ↑ Kaplan SA, Roehrborn CG, Rovner ES, Carlsson M, Bavendam T, Guan Z (2006). "Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial.". JAMA 296 (19): 2319-28. DOI:10.1001/jama.296.19.2319. PMID 17105794. Research Blogging.