Lamivudine: Difference between revisions

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imported>David E. Volk
imported>David E. Volk
(chem infobox)
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[[Image:Lamivudine structure.jpg|right|thumb|100px|{{#ifexist:Template:Lamivudine structure.jpg/credit|{{Lamivudine structure.jpg/credit}}<br/>|}}Lamivudine]]
 
{{Chem infobox
|align=right
|image=[[Image:Lamivudine structure.jpg|center|thumb|200px]]
|width=200px
|molname=lamivudine
|synonyms=  3TC, see Brand names
|molformula= C<sub>8</sub>H<sub>11</sub>N<sub>3</sub>O<sub>3</sub>S
|molmass= 229.2562
|uses=HIV
|properties=cytosine-like RT inhibitor
|hazards=see drug interactions
|iupac= see chemistry section
|casnumber=134678-17-4
}}


'''Lamivudine''' is a  nucleotide-based [[reverse transcriptase inhibitor]] used to treat [[HIV]]/[[AIDS]] and [[hepatitis B virus]]. It is an analog of [[zalcitabine]] that competes, in the triphosphate form, for incorporation in viral DNA with [[cytosine triphosphate]].  Lacking a 3'-OH group, it terminates DNA chain elongation because the phosphodiester bond necessary for elongation cannot be made.   
'''Lamivudine''' is a  nucleotide-based [[reverse transcriptase inhibitor]] used to treat [[HIV]]/[[AIDS]] and [[hepatitis B virus]]. It is an analog of [[zalcitabine]] that competes, in the triphosphate form, for incorporation in viral DNA with [[cytosine triphosphate]].  Lacking a 3'-OH group, it terminates DNA chain elongation because the phosphodiester bond necessary for elongation cannot be made.   


Its IUPAC name is 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and it has chemical formula C<sub>8</sub>H<sub>11</sub>N<sub>3</sub>O<sub>3</sub>S.
Its IUPAC name is 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and it has chemical formula C<sub>8</sub>H<sub>11</sub>N<sub>3</sub>O<sub>3</sub>S, giving it a molecular mass of 229.2562 g/mol.




Revision as of 11:41, 24 March 2008

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Lamivudine structure.jpg
lamivudine
IUPAC name: see chemistry section
Synonyms: 3TC, see Brand names
Formula: C8H11N3O3S
 Uses: HIV
 Properties: cytosine-like RT inhibitor
 Hazards: see drug interactions
Mass (g/mol): CAS #:
229.2562 134678-17-4


Lamivudine is a nucleotide-based reverse transcriptase inhibitor used to treat HIV/AIDS and hepatitis B virus. It is an analog of zalcitabine that competes, in the triphosphate form, for incorporation in viral DNA with cytosine triphosphate. Lacking a 3'-OH group, it terminates DNA chain elongation because the phosphodiester bond necessary for elongation cannot be made.

Its IUPAC name is 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and it has chemical formula C8H11N3O3S, giving it a molecular mass of 229.2562 g/mol.


Brand names

single drug brand names

  • 3TC
  • Epivir
  • Epivir-HBV
  • Hepitec
  • Heptovir
  • Zeffix

brand mixtures

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)


External links

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