Second messenger system: Difference between revisions
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In [[biochemistry]] and [[signal transduction]], a '''second messenger system''' are "Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a [[hormone]] or [[neurotransmitter]]. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-[[cyclic AMP]] system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the [[cyclic GMP]] system"<ref>{{MeSH}}</ref> | In [[biochemistry]] and [[signal transduction]], a '''second messenger system''' are "Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a [[hormone]] or [[neurotransmitter]]. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-[[cyclic AMP]] system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the [[cyclic GMP]] system"<ref>{{MeSH}}</ref> | ||
In [[signal transduction]], [[cell surface receptor]]s may activate [[second messenger system]]s such as adenyl cyclase-[[cyclic AMP]] and [[cyclic GMP]] which then may activate [[protein kinase]]s which then affect downstream targets. | In [[signal transduction]], [[cell surface receptor]]s may activate [[second messenger system]]s such as adenyl cyclase-[[cyclic AMP]] and [[cyclic GMP]] which then may activate [[protein kinase]]s which then affect downstream targets (see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=receptor,kinase,G-protein-coupled&rid=mcb.figgrp.5742 figure]).<ref name="isbn0-7167-3136-3">{{cite book |author=Lodish, Harvey F. |authorlink= |editor= |others= |title=Molecular cell biology |edition= |language= |publisher=Scientific American Books |location=New York |year=1999 |origyear= |chapter=20.1. Overview of Extracellular Signaling|chapterurl=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.5717|pages= |quote= |isbn=0-7167-3136-3 |oclc= |doi= |url=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb |accessdate=}}</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 10:52, 9 July 2009
In biochemistry and signal transduction, a second messenger system are "Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system"[1]
In signal transduction, cell surface receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases which then affect downstream targets (see figure).[2]
References
- ↑ Anonymous (2024), Second messenger system (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Lodish, Harvey F. (1999). “20.1. Overview of Extracellular Signaling”, Molecular cell biology. New York: Scientific American Books. ISBN 0-7167-3136-3.