Mixed connective tissue disease
Jump to navigation
Jump to search
- See also: Scleroderma
Now understood to be a distinct disease, mixed connective tissue disease (MCTD) is variously considered an overlap (i.e., overlap connective tissue disease) between systemic lupus erythematosus (SLE), scleroderma, and polymyositis; a specific subset of scleroderma with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity.
Most patients with MCTD have autoantibodies characteristic of scleroderma, such as U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP), and have clinical Raynaud's phenomenon.