Lamivudine

lamivudine
IUPAC name: see chemistry section Synonyms: 3TC, see Brand names Formula: C8H11N3O3S
Uses:	HIV/AIDS & Hep. B
Properties:	cytosine-like RT inhibitor
Hazards:	see drug interactions
Mass (g/mol): CAS #: 229.2562 134678-17-4

Lamivudine is a nucleotide-based reverse transcriptase inhibitor used to treat HIV/AIDS and hepatitis B virus. It is an analog of zalcitabine that competes, in the triphosphate form, for incorporation in viral DNA with cytosine triphosphate. Lacking a 3'-OH group, it terminates DNA chain elongation because the phosphodiester bond necessary for elongation cannot be made.

Its IUPAC name is 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one and it has chemical formula C₈H₁₁N₃O₃S, giving it a molecular mass of 229.2562 g/mol.

Brand names

single drug brand names

• 3TC
• Epivir
• Epivir-HBV
• Hepitec
• Heptovir
• Zeffix

brand mixtures

• Combivir (Lamivudine + Zidovudine)
• Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
• Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

External links

• Lamivudine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Template:MedMaster
• Template:DrugBank