User:Fred Salsbury

Fred Salsbury.

I am a theoretical biophysicist at Wake Forest University. See my webpage for more info.

Abbreviated CV

RESEARCH POSITIONS AND EXPERIENCE

2003-present Member, Comprehensive Cancer Center, Wake Forest University

2003-present Member, Center for Structural Biology, Wake Forest University

2002-present Assistant Professor, Department of Physics, Wake Forest University

1999-2002 Post-doctoral Fellow, Biophysics NSRA. Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA. Conducted research with Drs. Charles L. Brooks, III and Louis Noodleman.

1995-1999 Graduate Student Research Assistant, Materials Sciences Division, Lawrence Berkeley National Laboratory. Conducted research in the laboratory of Dr. Alexander Pines and with Dr. Robert A. Harris in the Department of Chemistry, University of California, Berkeley.

1995 Summer Student Research Assistant, Department of Chemistry, Brookhaven National Laboratory. Conducted research in the laboratory of Dr. Trevor Sears.

1994 Undergraduate Student Researcher, James Franck Institute, The University of Chicago. Conducted research in the laboratory of Dr. Stuart A. Rice.

TEACHING POSITIONS AND EXPERIENCE

2005-present Faculty member, (undergraduate) Track in Biochemistry and Biophysics

2004-present Faculty member, (Graduate) Track in Structural and Computational Biophysics (SCB)

2002-present Assistant Professor, Department of Physics, Wake Forest University Courses taught included the following: Introductory Physics (Mechanics, E&M, Optics and Nuclear), Intermediate Mechanics (Sophomore Level), Physics of Biological Macromolecules (Graduate level), Computational Molecular Biophysics Laboratory (Graduate level), Intermediate Laboratory (Computational; Sophomore Mechanics). Biophysics Journal Club (supervised)

1998-1999 Discussion Leader and Tutor, Student Learning Center University of California, Berkeley.

1995-1999 Graduate Student Teaching Assistant, Department of Chemistry, University of California, Berkeley

1992-1995 Reader, Department of Mathematics, The University of Chicago

EDUCATION AND TRAINING

Post-doctoral Fellow, Biophysics, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 1999-2002

Ph.D. Chemistry. University of California, Berkeley, CA, 1999 (Conducted research in chemical physics)

B. S. Mathematics and Chemistry, The University of Chicago, 1995

PUBLICATIONS

(excluding published abstracts; excluding papers submitted or in preparation)

18) M, H. Knaggs, F. R. Salsbury Jr., M. H. Edgell and J. S. Fetrow, Insights into Correlated Motion and Long-range Interactions in CheY Derived from Molecular Dynamics Simulation, Biophysics Journal, accepted, 2006

17) F. R. Salsbury, Jr, Clodfelter, J. E., Gentry, M. B., Hollis, T., Drotschmann, K., The molecular mechanism of DNA damage recognition by MutS homologs and its distinction from mismatch binding , Nucleic Acids Research, 34 (8) 2173-2185 (2006)

16) F. R. Salsbury, Jr,. Analysis of Errors in Stil’s Equation for Macromolecular Electrostatic Solvation Energies, Molecular Physics, 104 (8) 1299-1309 (2006)

15) M.S. Lee, F. R. Salsbury, Jr., and M. A. Olson, An Efficient Hybrid Implicit/Explicit Solvent Method for Biomolecular Simulations that Uses A Generalized Born Reaction Field and Multigrid Enhancements, J Comput Chem. 25 (16) 1967-78 (2004).

14) M. S. Lee, F. R. Salsbury, Jr., and C. L. Brooks, III, Constant pH-molecular Dynamics using Continuous Titration Coordinate, Proteins: Structure, Function and Bioinformatics, 56 (4):738-752 (2004).

13) L. R. Thomas, A. Henson, J. C. Reed, F. R. Salsbury, Jr., and A. Thorburn, Direct Binding of FADD to the TRAIL Receptor DR5 is Regulated by the Death Effector Domain of FADD, J. Bio. Chem. 279, 31 (2004).

12) K. Drotschmann, R. P. Topping, J. E. Clodfelter, and F. R. Salsbury, Jr, Mutations in the Nucleotide-binding Domain of MutS Homologs Uncouple Cell Death from Cell Survival, DNA Repair, 3 (7):729-742 (2004).

11) F. R. Salsbury, Jr, W-G. Han, L. Noodleman and C.L. Brooks, III, Temperature-dependent behavior of protein-chromophore interactions: a theoretical study of a blue fluorescent antibody , Chemphyschem 4 (8): 848-855 (2003)

10) M. S. Lee, M. Feig, F. R. Salsbury, Jr., and C. L. Brooks, III, A New Analytical Approximation to the Standard Molecular Volume Definition and Its Application To Generalized Born Calculations , Journal of Computational Chemistry 24 (11): 1348-1356 (2003)

9) M.S. Lee, F. R. Salsbury, Jr, and C.L. Brooks, III, New and Novel Generalized Born Methods, J. Chem. Phys., 116 (24), 10606-10614 (2002).

8) F. R. Salsbury, Jr, M. F. Crowley, and C. L. Brooks, III, Modeling of the metallo-beta-lactamase from B. fragilis: Structural and dynamic effects of inhibitor binding, Proteins: Structure, Function, & Genetics 44(4) 448-459 (2001)

7) F. R. Salsbury, Jr., and R. A. Harris, On the origin of the magnetic field dependent quadrupolar splitting, J. Chem. Phys., 109 (19), 8338-8341 (1998).

6) R. A. Harris, and F. R. Salsbury, Jr., The exchange energy in a weak magnetic field, J. Chem. Phys., 109 (7), 2609-2613 (1998).

5) F. R. Salsbury, Jr., and R. A. Harris, Estimation of the Fermi Contact Contribution to the Xenon-Hydrogen and Xenon-Xenon Spin-Spin Coupling Constants, Mol. Phys. 94 (2), 307-312 (1998).

4) F. R. Salsbury, Jr., and R. A. Harris, A nonlocal current density functional for magnetic responses , J. Chem. Phys. 108 (15), 6102-6108 (1998).

3) F. R. Salsbury, Jr., and R. A. Harris, Hydrogen chemical shieldings: A magnetic field density functional approach, Chem. Phys. Lett., 279 (3,4), 247-251 (1997).

2) F. R. Salsbury, Jr., and R. A. Harris, The current in magnetic field density functional theory and its application to the chemical shielding and the magnetic susceptibility, J. Chem. Phys., 107 (18), 7350-7359 (1997).

1) F. R. Salsbury, Jr., and R. A. Harris, Magnetic Field Density Functional Studies of NMR Parameters, The NMR Newsletter, 469, 21-22 October 1997.

PRESENTATIONS

F. R. Salsbury Jr. Computational Studies of a DNA Mismatch Repair Protein Invited Speaker, Symposium on “Modeling as a Tool in Biophysics”, 2007 Biophysical Society Meeting, Baltimore, MD March 3-7

F. R. Salsbury Jr. Computational Studies of DNA Repair Proteins Invited Speaker, 2006 Carolina Biophysics Symposium, Raleigh, NC November 1-3

F. R. Salsbury Jr, S. A. Knutson, L. A. Poole, and J. S. Fetrow. Structure and Sequence analysis of Cysteine Sulfenic Acid Modification 2006 Gordon Research Conference, Thiol-Based Redox Regulation & Signaling, June 18-23

M. H. Knaggs, Y. Yuan, L. A. Poole, J. S. Fetrow, and F. R. Salsbury Jr. Active site asymmetry in typical and atypical peroxiredoxin dimers 2006 Gordon Research Conference, Thiol-Based Redox Regulation & Signaling, June 18-23

F. R. Salsbury Jr., S. A. Knutson, L. A. Poole and J. S. Fetrow. Electrostatic Calculation of pKa Shifts in Proteins. 2005 Biophysical Society Meeting, Long Beach, CA

M. H. Knaggs, F. R. Salsbury Jr., M. H. Edgell, and J. S. Fetrow. Insights into early events in CheY relaxation from active to inactive form from MD simulation. Protein Society National Meeting, August 2005

N. A. W. Holzwarth, P. Tang, F. R. Salsbury, Jr., and J. Qualls. The electronic structure of zeta-BEDT-TTF PF6: a comparison of self-consistent field and Hubbard model analyses March APS 2005 Meeting, Los Angeles

F. R. Salsbury Jr., and J. Hill. Developments in Local and Nonlocal Functionals in Magnetic Field Density Functional Theory. American Physical Society Spring Meeting, Montreal, Canada, March 2004

F. R. Salsbury Jr., and M. S. Lee. Constant-pH Molecular dynamics: Principles and Applications. American Physical Society Spring Meeting, Montreal, March 2004

K. Drotschmann, J. E. Clodfelter, R. P. Topping and F. R. Salsbury Jr. Separation of function mutants in MutS homologs uncouple cell death from cell survival. American Association for Cancer Research National Meeting, March 2004

S. A. Knutson, F. R. Salsbury Jr., L. A. Poole, and J. S. Fetrow. Sequence, Structure, and Electrostatic Analysis of Sites of Cysteine Sulfenic Acid Modification in Proteins. 2004 Gordon Research Conference, Enzymes, Coenzymes, & Metabolic Pathways

F. R. Salsbury Jr. Constant-pH Molecular Dynamics. Invited Seminar: Old Dominion University Department of Chemistry, October 2004

F. R. Salsbury Jr. and M. S. Lee. Macromolecular Simulations with New Generalized Born Methods. American Physical Society National Meeting, Austin TX, March 2003

M. S. Lee, F. R. Salsbury Jr., C. L. Brooks, III. New trends in generalized Born implicit solvent methods. American Chemical Society National Meeting, March 2003

F. R. Salsbury Jr, Probing the dynamics and electrostatics of proteins. Department of Physics. Wake Forest University February 2002

F. R. Salsbury Jr, The dynamics of a blue fluorescent antibody and a metallo-beta-lactamase, University of Notre Dame, Department of Chemistry October 2001

F. R. Salsbury Jr., and C. L. Brooks, III, Computational studies of a metallo-beta-lactamase. American Chemical Society National meeting, Spring 2001

F. R. Salsbury Jr., and C. L. Brooks, III, Computational investigations of the metallo-beta-lactamase from B. fragile. American Chemical Society National meeting, Spring 2000

F. R. Salsbury Jr., and R. A. Harris, New Functionals in Magnetic Field Density Functional Theory and their applications to molecular responses, International Conference on Quantum Chemical Calculations of NMR and EPR Parameters, Castle Smolenice, Slovak Republic, September 14-18 1998

F. R. Salsbury Jr., and R. A. Harris, New Functionals in Magnetic Field Density Functional Theory, American Physical Society National Meeting March 1998 Los Angeles

F. R. Salsbury Jr., and R. A. Harris, BDFT: An introduction, Invited Talk, “Atoms in Strong Magnetic Fields” conference, CECAM, Lyon, France 1998

F. R. Salsbury Jr., and R. A. Harris, Recent Work in Magnetic Field Density Functional Theory, Experimental Nuclear Magnetic Resonance Conference, Asilonmar, 1997

F. R. Salsbury Jr., and R. A. Harris, Some Work in Magnetic Field Density Functional Theory, American Physical Society National Meeting March 1997 Kansas City

F. R. Salsbury Jr., Magnetic Field Density Functional Theory, Graduate Research Presentation, Department of Chemistry, University of California, Berkeley, Spring 1997

PROFESSIONAL SOCIETIES

American Physical Society

American Chemical Society

Biophysical Society

Protein Society