Mixed connective tissue disease
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- See also: Scleroderma
Now understood to be a distinct disease, mixed connective tissue disease (MCTD) is variously considered an overlap between systemic lupus erythematosus, scleroderma, and polymyositis; a specific subest of scleroderma with objective features of other diseases, such as SLE or polymyositis; or a distinct disease entity.
Most patients with MCTD have autoantibodies to U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP),