Pyrroloquinoline quinone

Pyrroloquinoline quinone (PQQ) was originally discovered in 1978 in methanol dehydrogenase fom 'Hyphomicrobium' X. It is present as a non-covalently bound cofactor in several bacterial dehydrogenases involved in the oxidation of alcohols ans sugars. The biochemically relevant redox states are the fully oxidized quinone form, the radical semiquinone form and the reduced quinol. The reduced form is only stable when bound to enzyme or at low pH, whereas the semiquinone is only stable at high pH and anerobic conditions.

PQQ was reported to be a vitamin in mice on April 24 2003 by a research team led by Takafumi Kato of the Japanese Institute of Physical and Chemical Research (source). However, these conclusions have been strongly challenged.

References

• Role of PQQ as a mammalian enzyme cofactor? [Leigh M. Felton, Chris Anthony School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK e-mail: c.anthony@soton.ac.uk doi:10.1038/nature03322]
• Is pyrroloquinoline quinone a vitamin? [Robert Rucker*, David Storms*, Annemarie Sheets*, Eskouhie Tchaparian*,Andrea Fascetti† Departments of *Nutrition, College of Agriculture and Environmental Sciences, and †Molecular Bioscience, School of Veterinary Medicine, University of California, Davis, California 95616, USA e-mail: rbrucker@ucdavis.edu doi:10.1038/nature03323]