Adrenergic beta-antagonist: Difference between revisions
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* [http://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Carvedilol Carvedilol] | * [http://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Carvedilol Carvedilol] | ||
* Labetalol | * Labetalol | ||
==Clinical uses== | |||
The individual beta-blockers have been compared in the treatment of various diseases.<ref name="PubmedClinicalQ&A">{{cite book |author=Dean L |authorlink= |editor= |others= |title= PubMed Clinical Q&A |edition= | |||
|chapter=Comparing Beta Blockers | |||
|chapterurl=http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=ebm&part=bb | |||
|language= |publisher=National Library of Medicine (US), National Center for Biotechnology Information |location=Bethesda (MD) |year=2007 |origyear= |pages= |quote=Based on http://www.ohsu.edu/drugeffectiveness/ |isbn= |oclc= |doi= |url=http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=ebm |accessdate=}}</ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 15:14, 10 September 2008
Adrenergic beta-receptor blockaders (beta-blockers) are "drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety".[1]
Beta-blockers vary within the class regarding their properties. Beta-blockers that have low intrinsic sympathomimetic activity (ISA), low membrane stabilizing activity, high beta 1-selectivity, and high lipophilicity may be more effective.[2] A meta-analysis has concluded that metoprolol may be the best beta-blocker for secondary prevention of myocardial infarction.[2]
Availability
Generically available beta-blockers include:[3][4]
- Betaxolol
- Nadolol
- Propranolol
- Timolol
Generic beta-blockers with beta 1-selectivity:[2]
- Atenolol (less lipid soluble; renally excreted)
- Bisoprolol
- Metoprolol (hepatically metabolized by cytochrome P-450)
Generic beta-blockers with intrinsic sympathomimetic activity (less resting bradycardia and lipid changes):[3]
- Acebutolol
- Pindolol
Generic beta-blockers with alpha blocking activity (more orthostatic hypotension):[3]
- Carvedilol
- Labetalol
Clinical uses
The individual beta-blockers have been compared in the treatment of various diseases.[5]
References
- ↑ Anonymous (2024), Adrenergic beta-antagonist (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 2.2 Soriano JB, Hoes AW, Meems L, Grobbee DE (1997). "Increased survival with beta-blockers: importance of ancillary properties". Prog Cardiovasc Dis 39 (5): 445–56. PMID 9122425. [e]
- ↑ 3.0 3.1 3.2 (June 2005) "Drugs for hypertension". Treat Guidel Med Lett 3 (34): 39–48. PMID 15912125. [e]
- ↑ (March 2008) "Nebivolol (Bystolic) for hypertension". Med Lett Drugs Ther 50 (1281): 17–9. PMID 18323772. [e]
- ↑ Dean L (2007). “Comparing Beta Blockers”, PubMed Clinical Q&A. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information. “Based on http://www.ohsu.edu/drugeffectiveness/”