Adrenergic beta-antagonist: Difference between revisions
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'''Adrenergic beta-receptor blockaders''' ('''beta-blockers''') are "drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of [[hypertension]], cardiac arrhythmias, angina pectoris, glaucoma, [[migraine]] headaches, and anxiety".<ref>{{MeSH}}</ref> | '''Adrenergic beta-receptor blockaders''' ('''beta-blockers''') are "drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of [[hypertension]], cardiac arrhythmias, angina pectoris, glaucoma, [[migraine]] headaches, and anxiety".<ref>{{MeSH}}</ref> | ||
Beta-blockers vary within the class regarding intrinsic sympathomimetic activity (ISA), [[Adrenergic receptor|beta 1-selectivity]], | Beta-blockers vary within the class regarding their properties. Beta-blockers that have low intrinsic sympathomimetic activity (ISA), low membrane stabilizing activity, high [[Adrenergic receptor|beta 1-selectivity]], and high lipophilicity may be more effective.<ref name="pmid9122425">{{cite journal |author=Soriano JB, Hoes AW, Meems L, Grobbee DE |title=Increased survival with beta-blockers: importance of ancillary properties |journal=Prog Cardiovasc Dis |volume=39 |issue=5 |pages=445–56 |year=1997 |pmid=9122425 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0033-0620(97)80039-4 |issn=}}</ref> A [[meta-analysis]] has concluded that [[metoprolol]] may be the best beta-blocker for [[secondary prevention]] of [[myocardial infarction]].<ref name="pmid9122425"/> | ||
==Availability== | ==Availability== | ||
Revision as of 01:21, 20 May 2008
Adrenergic beta-receptor blockaders (beta-blockers) are "drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety".[1]
Beta-blockers vary within the class regarding their properties. Beta-blockers that have low intrinsic sympathomimetic activity (ISA), low membrane stabilizing activity, high beta 1-selectivity, and high lipophilicity may be more effective.[2] A meta-analysis has concluded that metoprolol may be the best beta-blocker for secondary prevention of myocardial infarction.[2]
Availability
Generically available beta-blockers include:[3][4]
- Atenolol (renally excreted)
- Betaxolol
- Bisoprolol
- Metoprolol (hepatically metabolized by cytochrome P-450)
- Nadolol
- Propranolol
- Timolol
Generic beta-blockers with intrinsic sympathomimetic activity (less resting bradycardia and lipid changes):[3]
- Acebutolol
- Pindolol
Generic beta-blockers with alpha blocking activity (more orthostatic hypotension):[3]
- Carvedilol
- Labetalol
References
- ↑ Anonymous (2024), Adrenergic beta-antagonist (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 Soriano JB, Hoes AW, Meems L, Grobbee DE (1997). "Increased survival with beta-blockers: importance of ancillary properties". Prog Cardiovasc Dis 39 (5): 445–56. PMID 9122425. [e]
- ↑ 3.0 3.1 3.2 (June 2005) "Drugs for hypertension". Treat Guidel Med Lett 3 (34): 39–48. PMID 15912125. [e]
- ↑ (March 2008) "Nebivolol (Bystolic) for hypertension". Med Lett Drugs Ther 50 (1281): 17–9. PMID 18323772. [e]