Antineoplastic agent: Difference between revisions
imported>Robert Badgett (New page: {{subpages}} In medicine, '''antineoplastic agents''' are "substances that inhibit or prevent the proliferation of neoplasms".<ref>{{MeSH}}</ref> Generally, antineoplastic agents are f...) |
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===Alkylating agents=== | ===Alkylating agents=== | ||
ATC/DDD group [http://www.whocc.no/atcddd/indexdatabase/index.php?query=L01A L01A]. | ATC/DDD group [http://www.whocc.no/atcddd/indexdatabase/index.php?query=L01A L01A]. Alkylating antineoplastic agents are a "class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood."<ref>{{MeSH|Antineoplastic Agents, Alkylating}}</ref> | ||
==== Nitrogen mustard analogues==== | ==== Nitrogen mustard analogues==== | ||
Revision as of 20:26, 4 February 2009
In medicine, antineoplastic agents are "substances that inhibit or prevent the proliferation of neoplasms".[1] Generally, antineoplastic agents are for treating malignant neoplasms such as cancers and sarcomas.
Classification
This classification is based on World Health Organization's Collaborating Centre for Drug Statistics Methodology.[2]
Alkylating agents
ATC/DDD group L01A. Alkylating antineoplastic agents are a "class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood."[3]
Nitrogen mustard analogues
ATC/DDD group L01AA.
Alkyl sulfonates
ATC/DDD group L01AB.
Ethylene imines
ATC/DDD group L01AC.
Nitrosoureas
ATC/DDD group L01AD.
Epoxides
ATC/DDD group L01AG.
Other alkylating agents
ATC/DDD group L01AX.
Antimetabolites
ATC/DDD group L01B.
Folic acid analogues
ATC/DDD group L01BA.
Purine analogues
ATC/DDD group L01BB.
Pyrimidine analogues
ATC/DDD group L01BC.
Plant alkaloids and other natural products
ATC/DDD group L01C.
Vinca alkaloids and analogues
ATC/DDD group L01CA.
Podophyllotoxin derivatives
ATC/DDD group L01CB.
Colchicine derivatives
ATC/DDD group L01CC.
Taxanes
ATC/DDD group L01CD.
Other plant alkaloids and natural products
ATC/DDD group L01CX.
ATC/DDD group L01D.
Actinomycines
ATC/DDD group L01DA.
ATC/DDD group L01DB.
Other cytotoxic antibiotics
ATC/DDD group L01DC.
Other antineoplastic agents
ATC/DDD group L01X.
Platinum compounds
ATC/DDD group L01XA.
Methylhydrazines
ATC/DDD group L01XB.
Monoclonal antibodies
ATC/DDD group L01XC.
Sensitizers used in photodynamic/radiation therapy
ATC/DDD group L01XD.
Protein kinase inhibitors
ATC/DDD group L01XE.
References
- ↑ Anonymous (2024), Antineoplastic agent (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous. WHO Collaborating Centre for Drug Statistics Methodology. World Health Organization. Retrieved on 2009-02-04.
- ↑ Anonymous (2024), Antineoplastic Agents, Alkylating (English). Medical Subject Headings. U.S. National Library of Medicine.