Bisoprolol: Difference between revisions

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{{subpages}}
{{subpages}}
{{Chem infobox
|align=right
|image={{Image|Bisoprolol.png|center|300px|Structure of Bisoprolol.}}
|width=300px
|molname=Bisoprolol
|synonyms=
|molformula= C<sub>18</sub>H<sub>31</sub>NO<sub>4</sub>
|molmass= 266.34
|uses=adrenergic beta-antagonist
|properties=
|hazards=
|iupac=
|casnumber= 66722-44-9
}}
In [[medicine]], '''bisoprolol''' is a "cardioselective [[adrenergic beta-antagonist|beta-1-adrenergic blocker]]. It is effective in the management of [[hypertension]] and [[angina pectoris]]."<ref>{{MeSH}}</ref>
In [[medicine]], '''bisoprolol''' is a "cardioselective [[adrenergic beta-antagonist|beta-1-adrenergic blocker]]. It is effective in the management of [[hypertension]] and [[angina pectoris]]."<ref>{{MeSH}}</ref>


Variation in the effects of bisoprolol may be due to adrenergic receptor genotypes.<ref name="pmid17585213">{{cite journal |author=Zaugg M, Bestmann L, Wacker J, ''et al'' |title=Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up |journal=Anesthesiology |volume=107 |issue=1 |pages=33–44 |year=2007 |month=July |pmid=17585213 |doi=10.1097/01.anes.0000267530.62344.a4 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00000542-200707000-00010 |issn=}}</ref>
Variation in the effects of bisoprolol may be due to adrenergic receptor genotypes.<ref name="pmid17585213">{{cite journal |author=Zaugg M, Bestmann L, Wacker J, ''et al'' |title=Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up |journal=Anesthesiology |volume=107 |issue=1 |pages=33–44 |year=2007 |month=July |pmid=17585213 |doi=10.1097/01.anes.0000267530.62344.a4 |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00000542-200707000-00010 |issn=}}</ref>
==History==
Bisoprolol fumarate was approved in 1992.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=ZEBETA Drugs@FDA]. U S Food and Drug Administration</ref> [[Generic drug|Generic]] bisoprolol was approved in 2002.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Set_Current_Drug&ApplNo=075474&DrugName=BISOPROLOL%20FUMARATE&ActiveIngred=BISOPROLOL%20FUMARATE&SponsorApplicant=MUTUAL%20PHARM&ProductMktStatus=3 Drugs@FDA]. U S Food and Drug Administration</ref>


==Metabolism==
==Metabolism==
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==Dosage==
==Dosage==
For healthy adults, the starting dose is 5 mg orally per day (sometimes 2.5 mg) and the maximum dose is 10 to 20 mg orally per day.
For healthy adults, the starting dose is 5 mg orally per day (sometimes 2.5 mg) and the maximum dose is 10 to 20 mg orally per day.
== Synoyms and Brand Names ==
''Synonyms''
* bisoprolol fumarate
* bisoprolol hemifumarate
* bisoprolol fumerate
''Brand Names''
*Cardicor
*Concor
*Condyline
*Condylox
*Detensiel
*Emconcor
*Emcor
*Euradal
*Isoten
*Monocor
*Soloc
*Soprol
*Zebeta


==External links==
==External links==

Latest revision as of 14:09, 4 July 2009

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© Image: David E. Volk
Structure of Bisoprolol.
Bisoprolol
IUPAC name:
Synonyms:
Formula: C18H31NO4
 Uses: adrenergic beta-antagonist
 Properties:
 Hazards:
Mass (g/mol): CAS #:
266.34 66722-44-9



In medicine, bisoprolol is a "cardioselective beta-1-adrenergic blocker. It is effective in the management of hypertension and angina pectoris."[1]

Variation in the effects of bisoprolol may be due to adrenergic receptor genotypes.[2]

History

Bisoprolol fumarate was approved in 1992.[3] Generic bisoprolol was approved in 2002.[4]

Metabolism

It is not metabolized by cytochrome P-450 2D6 allele.

Dosage

For healthy adults, the starting dose is 5 mg orally per day (sometimes 2.5 mg) and the maximum dose is 10 to 20 mg orally per day.

Synoyms and Brand Names

Synonyms

  • bisoprolol fumarate
  • bisoprolol hemifumarate
  • bisoprolol fumerate

Brand Names

  • Cardicor
  • Concor
  • Condyline
  • Condylox
  • Detensiel
  • Emconcor
  • Emcor
  • Euradal
  • Isoten
  • Monocor
  • Soloc
  • Soprol
  • Zebeta


External links

The most up-to-date information about Bisoprolol and other drugs can be found at the following sites.


References

  1. ↑ Anonymous (2024), Bisoprolol (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Zaugg M, Bestmann L, Wacker J, et al (July 2007). "Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up". Anesthesiology 107 (1): 33–44. DOI:10.1097/01.anes.0000267530.62344.a4. PMID 17585213. Research Blogging.
  3. ↑ Drugs@FDA. U S Food and Drug Administration
  4. ↑ Drugs@FDA. U S Food and Drug Administration
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