Borna disease virus: Difference between revisions

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==Description and significance==
==Description and significance==


A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,<ref>Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.</ref> including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis<ref>Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82</ref> to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.
A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,<ref name=Richt>Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.</ref> including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis<ref>Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82</ref> to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.


==Genome structure==
==Genome structure==

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Borna disease virus
Scientific classification
Order: Mononegavirales
Family: Bornaviridae
Genus: Bornavirus
Species: Borna disease virus


Description and significance

A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,[1] including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis[2] to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.

Genome structure

Borna disease virus has a genome size of approximately 9 kb

Cell structure and metabolism

Ecology

Pathology

Application to Biotechnology

Current Research

References

  1. ↑ Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.
  2. ↑ Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82
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