Brain natriuretic peptide: Difference between revisions
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In [[medicine]], '''brain natriuretic peptide''' ('''BNP''') is a "peptide that is secreted by the brain and the heart atria, stored mainly in cardiac ventricular myocardium. It can cause natriuresis; diuresis; vasodilation; and inhibits secretion of renin and aldosterone. It improves heart function. It contains 32 amino acids."<ref>{{MeSH}}</ref> | In [[medicine]], '''brain natriuretic peptide''' ('''BNP''') is a "peptide that is secreted by the brain and the heart atria, stored mainly in cardiac ventricular myocardium. It can cause natriuresis; diuresis; vasodilation; and inhibits secretion of renin and aldosterone. It improves heart function. It contains 32 amino acids."<ref>{{MeSH}}</ref> | ||
BNP is one member or a family of closely related peptides called "natriuretic peptides" because of their ability to stimulate sodium excretion ([[natriuresis]]). Natriuretic peptides are functional antagonists to the [[renin-angiotensin-aldosterone system]]. | BNP is one member or a family of closely related peptides called "natriuretic peptides" because of their ability to stimulate sodium excretion ([[natriuresis]]). Natriuretic peptides are functional antagonists to the [[renin-angiotensin-aldosterone system]]. BNP was given its name because it was first discovered in the porcine brain. <ref> Baxter GF (2004) The natriuretic peptides. '' | ||
Basic Res Cardiol'' 99:71-5. PMID 14963664</ref> However, confusingly, there appears to be relatively little BNP expressed in the brain compared to [[atrial natriuretic peptide]] <ref>Langub MC ''et al.'' (1995) Distribution of natriuretic peptide precursor mRNAs in the rat brain. ''J Comp Neurol'' 356:183-99. PMID 7629314</ref> | |||
An elevated concentration of BNP in the circulation can detect [[heart failure]]:<ref name="pmid12124404">{{cite journal |author=Maisel AS, Krishnaswamy P, Nowak RM, ''et al'' |title=Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure |journal=N Engl J Med |volume=347 |pages=161–7 |year=2002 |month=July |pmid=12124404 |doi=10.1056/NEJMoa020233 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12124404&promo=ONFLNS19 |issn=}}</ref> | An elevated concentration of BNP in the circulation can detect [[heart failure]]:<ref name="pmid12124404">{{cite journal |author=Maisel AS, Krishnaswamy P, Nowak RM, ''et al'' |title=Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure |journal=N Engl J Med |volume=347 |pages=161–7 |year=2002 |month=July |pmid=12124404 |doi=10.1056/NEJMoa020233 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12124404&promo=ONFLNS19 |issn=}}</ref> | ||
Revision as of 10:01, 6 February 2009
In medicine, brain natriuretic peptide (BNP) is a "peptide that is secreted by the brain and the heart atria, stored mainly in cardiac ventricular myocardium. It can cause natriuresis; diuresis; vasodilation; and inhibits secretion of renin and aldosterone. It improves heart function. It contains 32 amino acids."[1]
BNP is one member or a family of closely related peptides called "natriuretic peptides" because of their ability to stimulate sodium excretion (natriuresis). Natriuretic peptides are functional antagonists to the renin-angiotensin-aldosterone system. BNP was given its name because it was first discovered in the porcine brain. [2] However, confusingly, there appears to be relatively little BNP expressed in the brain compared to atrial natriuretic peptide [3]
An elevated concentration of BNP in the circulation can detect heart failure:[4]
| Sensitivity | Specificity | |
|---|---|---|
| BNP > 100 pg per milliliter | 90% | 76% |
| BNP > 50 pg per milliliter | 97% | 62% |
References
- ↑ Anonymous (2024), Brain natriuretic peptide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Baxter GF (2004) The natriuretic peptides. Basic Res Cardiol 99:71-5. PMID 14963664
- ↑ Langub MC et al. (1995) Distribution of natriuretic peptide precursor mRNAs in the rat brain. J Comp Neurol 356:183-99. PMID 7629314
- ↑ 4.0 4.1 Maisel AS, Krishnaswamy P, Nowak RM, et al (July 2002). "Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure". N Engl J Med 347: 161–7. DOI:10.1056/NEJMoa020233. PMID 12124404. Research Blogging.