Diabesity/Bibliography

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Review Articles

1. Magni P. et al. (2009) Feeding behavior in mammals including humans. Ann.N.Y.Acad.Sci. 1163:221-232. PMID 19456343

JOHN PARK BIBLIOGRAPHY (WILL SORT THIS OUT SOON)

1) Speakman J. et al. (2008) Thrifty vs Drifty Gene Theory of Obesity Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis. International Journal of Obesity (2008) 32, 1611–1617 The discussion of thrifty genes and drifty genes, on obesity and diabetes. Suggestion made that the case for Thrifty genes may not be correct, but rather a different hypothesis is proposed

2. Cameron, N et al. (2006) Childhood Obesity Contemporary Issues, p154, CRC press, Taylor and Francis Group. Discusses how obesity relates very closely to Diabetes. Relates genetic and environmental factors and summarises the thrifty gene hypothesis .

3. Marchand L, (2002) The Pima Indians: Pathfinders for health, Obesity and Diabetes, Online resource: http://diabetes.niddk.nih.gov/DM/pubs/pima/obesity/obesity.htm NIDDK research conducted on the Pima Indians for the past 30 years has helped scientists prove that obesity is a major risk factor in the development of diabetes. One-half of adult Pima Indians have diabetes and 95% of those with diabetes are overweight. Scientists use the "thrifty gene" theory proposed in 1962 by geneticist James Neel to help explain why many Pima Indians are overweight

4. Neel JV (1962). "Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?". Am. J. Hum. Genet. 14: 353–62. PMID 13937884.

The original paper that proposes the Thrifty genotype.

Again evidence that suggests the Thrifty genotype in Type 2 diabetes. And obesity Joffe, Barry; Paul Zimmet (1998-08-17). "The thrifty genotype in type 2 diabetes". Endocrine 9 (2): 139–141. doi:10.1385/ENDO:9:2:139.

KATIE ROWLAND REFERENCES - will also sort out fully soon! Katie Rowland 09:27, 20 October 2009 (UTC) My references - I have looked into treatment of diabetes/obesity - thought could maybe do how treating obesity will reduce diabetes? if its not along the right lines just let me know and i will change it!

1. Tamara S. Hannon, MD, Goutham Rao, MD and Silva A. Arslanian, MD. Childhood Obesity and Type 2 Diabetes Mellitus. Pediatrics. 2005;116: 473-480.

2. J. Garber. Restaging insulin therapy for patients with type 2 diabetes. Diabetes Obes Metab. 2009;11: 1–5.

3. Monami M, Lamanna C, Marchionni N et al. Comparison of different drugs as add-on treatments to metformin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pr. 2008; 79: 196–203.

4. Jermendy G. Can type 2 diabetes mellitus be considered preventable? Diabetess res clin pr. 2005; 68, S73-S81

5. Diabetes Prevention Program Research Group, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N. Engl. J. Med. 346 (2002) 393–403.

6. Bray G. Drug Treatment of Obesity. Reviews in Endocrine & Metabolic Disorders. 2001; 2.

7. Chaputy JP and Tremblay A. Current and novel approaches to the drug therapy of obesity. Eur J Clin Pharmacol. 2006; 62

8. Lean MEJ, Powrie JK, Anderson AS, et al. Obesity, weight loss and prognosis in type 2 diabetes. Diabetic Med. 1990; 7:228-233.

9. Hartz AJ, Rupley DC Jr, Kalkhoff RD, et al : Relationship of obesity to diabetes: influences of obesity level and body fat distribution. Prev Med 1983; 12: 351-357

Primary Research Papers

Causes of type 2 diabetes in obese patients

Endoplasmic reticulum stress causing hyper-activation of Jun kinases (JNKs), which leads to phosphorylation of insulin receptor substrates (IRSs), inhibiting insulin signalling:

Umut Özcan, et al. (2004) Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes. Science 306, 457-461.

Giovanni Solinas, et al. (2007) JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity. Cell Metabolism 6, 386–397.

Dysfunction of the pancreatic β-cells, which do not produce or secrete enough insulin to compensate for insulin resistance:

Hiroshi Karasawaa, Seiko Nagata-Gotoa, Kiyosumi Takaishia and Yoshihiro Kumagae. (2009) A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice. Metabolism Clinical and Experimental 58, 296–303.

Alexandra Butler et al. (2003) β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes. Diabetes 52(1), 102-110.

Marc Donath et al. (2008) Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy. Diabetes Care 31(2), 161-164.

The hormone resistin, secreted by adipocytes, which causes resistance to insulin:

Claire M. Steppan, et al. (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312.

Mohammed Qatanani et al. (2009) Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. The Journal of Clinical Investigation 119(3), 531-539.
Nicholas Devlin 15:37, 26 October 2009 (UTC)

Hannah Frost references - have been looking at implications of obesity in pregnancy i.e. increased risks to both mother and fetus of later onset of T2DM/NIDDM

Yogev, Y. and Visser, G. (2009) Obesity, gestational diabetes and pregnancy outcome. Seminars in Fetal and Neonatal Medicine, Volume 14, Issue 2, Pages 77-84

Hattersley, A.T. and Tooke, J.E. (1999) The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease. Lancet. May 22;353(9166):1789-92.

Chu, S.Y. et al. (2007) Maternal Obesity and Risk of Gestational Diabetes Mellitus. Diabetes Care. Vol. 30, No. 8, Pages 2070-2076

Boney, C.M. et al. (2005) Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus. PEDIATRICS. Vol. 115, No. 3

http://www.webmd.com/baby/guide/pregnancy-gestational-diabetes

Dunger, D. and Ong, K. (2009) Diabetes in pregnancy: a vicious circle? Research Horizons. Issue 8.