G-protein-coupled receptor: Difference between revisions
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In [[biology]], '''G-protein-coupled receptors''' are the "largest family of [[cell surface receptor]]s involved in [[signal transduction]]. They share a common structure and signal through [[heterotrimeric g-proteins]]."<ref>{{MeSH}}</ref> | In [[biology]], '''G-protein-coupled receptors''' are the "largest family of [[cell surface receptor]]s involved in [[signal transduction]]. They share a common structure and signal through [[heterotrimeric g-proteins]]."<ref>{{MeSH}}</ref><ref name="pmid19458711">{{cite journal| author=Rosenbaum DM, Rasmussen SG, Kobilka BK| title=The structure and function of G-protein-coupled receptors. | journal=Nature | year= 2009 | volume= 459 | issue= 7245 | pages= 356-63 | pmid=19458711 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=19458711 | doi=10.1038/nature08144 }} </ref> | |||
In [[signal transduction]], [[cell surface receptor]]s such as | In [[signal transduction]], [[cell surface receptor]]s such as G-protein-coupled receptors may activate [[second messenger system]]s such as adenyl cyclase-[[cyclic AMP]] and [[cyclic GMP]] which then may activate [[protein kinase]]s such as [[G-protein-coupled receptor kinase]] which then affect downstream targets (see [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=receptor,kinase,G-protein-coupled&rid=mcb.figgrp.5742 figure]).<ref name="isbn0-7167-3136-3">{{cite book |author=Lodish, Harvey F. |authorlink= |editor= |others= |title=Molecular cell biology |edition= |language= |publisher=Scientific American Books |location=New York |year=1999 |origyear= |chapter=20.1. Overview of Extracellular Signaling|chapterurl=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.section.5717|pages= |quote= |isbn=0-7167-3136-3 |oclc= |doi= |url=http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb |accessdate=}}</ref> | ||
Two principal [[signal transduction]] pathways involving the G-protein coupled receptors are proposed: they use either the [[cyclic AMP]] or the phosphatidylinositol diphosphate-inositol triphosphate [[second messenger system]]s.<ref name="pmid3113327">{{cite journal |author=Gilman AG |title=G proteins: transducers of receptor-generated signals |journal=Annu. Rev. Biochem. |volume=56 |issue= |pages=615–49 |year=1987 |pmid=3113327 |doi=10.1146/annurev.bi.56.070187.003151 |url=http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.bi.56.070187.003151?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov |issn=}}</ref> | Two principal [[signal transduction]] pathways involving the G-protein coupled receptors are proposed: they use either the [[cyclic AMP]] or the phosphatidylinositol diphosphate-inositol triphosphate [[second messenger system]]s.<ref name="pmid3113327">{{cite journal |author=Gilman AG |title=G proteins: transducers of receptor-generated signals |journal=Annu. Rev. Biochem. |volume=56 |issue= |pages=615–49 |year=1987 |pmid=3113327 |doi=10.1146/annurev.bi.56.070187.003151 |url=http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.bi.56.070187.003151?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov |issn=}}</ref> | ||
Examples of G-protein-coupled receptors include [[adrenergic receptor]]s, [[angiotensin receptor]]s, [[bradykinin receptor]]s, [[CCR5 receptor]] (used by [[HIV]] to infect cells), | Examples of G-protein-coupled receptors include [[adrenergic receptor]]s, [[angiotensin receptor]]s, [[bradykinin receptor]]s, [[CCR5 receptor]] (used by [[HIV]] to infect cells), [[opioid receptor]]s, and [[purinoceptor P2Y12|purinoceptor P2Y<sub>12</sub>]] (causes platelet aggregation). | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Latest revision as of 13:08, 30 March 2010
In biology, G-protein-coupled receptors are the "largest family of cell surface receptors involved in signal transduction. They share a common structure and signal through heterotrimeric g-proteins."[1][2]
In signal transduction, cell surface receptors such as G-protein-coupled receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP and cyclic GMP which then may activate protein kinases such as G-protein-coupled receptor kinase which then affect downstream targets (see figure).[3]
Two principal signal transduction pathways involving the G-protein coupled receptors are proposed: they use either the cyclic AMP or the phosphatidylinositol diphosphate-inositol triphosphate second messenger systems.[4]
Examples of G-protein-coupled receptors include adrenergic receptors, angiotensin receptors, bradykinin receptors, CCR5 receptor (used by HIV to infect cells), opioid receptors, and purinoceptor P2Y12 (causes platelet aggregation).
References
- ↑ Anonymous (2024), G-protein-coupled receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Rosenbaum DM, Rasmussen SG, Kobilka BK (2009). "The structure and function of G-protein-coupled receptors.". Nature 459 (7245): 356-63. DOI:10.1038/nature08144. PMID 19458711. Research Blogging.
- ↑ Lodish, Harvey F. (1999). “20.1. Overview of Extracellular Signaling”, Molecular cell biology. New York: Scientific American Books. ISBN 0-7167-3136-3.
- ↑ Gilman AG (1987). "G proteins: transducers of receptor-generated signals". Annu. Rev. Biochem. 56: 615–49. DOI:10.1146/annurev.bi.56.070187.003151. PMID 3113327. Research Blogging.