Hemolytic anemia: Difference between revisions
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Hemolytic anemia associated with ''normal'' red cells | Hemolytic anemia associated with ''normal'' red cells | ||
* Autoimmune hemolytic anemia | * [[Autoimmune hemolytic anemia]] | ||
** Direct antiglobulin ("Coombs") test-negative | |||
** Direct antiglobulin ("Coombs") test-positive | |||
* Complement-induced lysis | * Complement-induced lysis | ||
* Microangiopathic hemolytic anemia | * [[Microangiopathic hemolytic anemia]]. Includes [[Thrombotic thrombocytopenic purpura]]. | ||
* Others | |||
Hemolytic anemia associated with ''abnormal'' red cells | Hemolytic anemia associated with ''abnormal'' red cells | ||
* Hemoglobinopathies | * Hemoglobinopathies. Includes [[Sickle cell anemia]]. | ||
* Metabolic deficiency | * Metabolic deficiency | ||
* Erythrocyte membrane abnormality | * Erythrocyte membrane abnormality. Includes [[Hereditary spherocytosis]]. | ||
* Others | |||
==Diagnosis== | ==Diagnosis== | ||
* [[Coombs' test]] | |||
* [[Haptoglobin]] has:<ref name="pmid7365971">{{cite journal| author=Marchand A, Galen RS, Van Lente F| title=The predictive value of serum haptoglobin in hemolytic disease. | journal=JAMA | year= 1980 | volume= 243 | issue= 19 | pages= 1909-11 | pmid=7365971 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7365971 }} </ref> | |||
** [[Sensitivity and specificity|Sensitivity]] 83% | |||
** [[Sensitivity and specificity|Specificity]] 96% | |||
* [[Lactate dehydrogenase]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 01:07, 22 December 2014
In hematology, Hemolytic anemia is an "A condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes)."[1]
Classification
One classification is based on whether hemolysis occurs intravascularly or extravascularly. Another classification is whether the erythrocytes are intrinsically normal:[2]
Hemolytic anemia associated with normal red cells
- Autoimmune hemolytic anemia
- Direct antiglobulin ("Coombs") test-negative
- Direct antiglobulin ("Coombs") test-positive
- Complement-induced lysis
- Microangiopathic hemolytic anemia. Includes Thrombotic thrombocytopenic purpura.
- Others
Hemolytic anemia associated with abnormal red cells
- Hemoglobinopathies. Includes Sickle cell anemia.
- Metabolic deficiency
- Erythrocyte membrane abnormality. Includes Hereditary spherocytosis.
- Others
Diagnosis
References
- ↑ Anonymous (2024), Hemolytic anemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Wright DE, Rosovsky RP, Platt MY (2013). "Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.". N Engl J Med 369 (21): 2032-43. DOI:10.1056/NEJMcpc1215972. PMID 24256382. Research Blogging.
- ↑ Marchand A, Galen RS, Van Lente F (1980). "The predictive value of serum haptoglobin in hemolytic disease.". JAMA 243 (19): 1909-11. PMID 7365971. [e]