Hypericum: Difference between revisions
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==Clinical purposes== | ==Clinical purposes== | ||
Hypericum may help treat mild depression.<ref name="pmid16973054">{{cite journal| author=Geddes J, Butler R, Hatcher S, Cipriani A, Price J, Carney S et al.| title=Depression in adults. | journal=Clin Evid | year= 2006 | volume= | issue= 15 | pages= 1366-406 | pmid=16973054 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16973054 }} </ref> | Hypericum may help treat mild depression.<ref name="pmid16973054">{{cite journal| author=Geddes J, Butler R, Hatcher S, Cipriani A, Price J, Carney S et al.| title=Depression in adults. | journal=Clin Evid | year= 2006 | volume= | issue= 15 | pages= 1366-406 | pmid=16973054 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16973054 }} </ref> | ||
One [[randomized controlled trial]] found no benefit<ref name="pmid11939866">{{cite journal| author=Hypericum Depression Trial Study Group| title=Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial. | journal=JAMA | year= 2002 | volume= 287 | issue= 14 | pages= 1807-14 | pmid=11939866 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11939866 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12440452 Review in: Evid Based Ment Health. 2002 Nov;5(4):111] </ref>, whereas a subsequent trial using a higher dose of hypericum (900 mg/day hypericum extract three times a day) found benefit<ref name="pmid15708844">{{cite journal| author=Szegedi A, Kohnen R, Dienel A, Kieser M| title=Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine. | journal=BMJ | year= 2005 | volume= 330 | issue= 7490 | pages= 503 | pmid=15708844 | doi=10.1136/bmj.38356.655266.82 | pmc=PMC552808 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15708844 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16246883 Review in: Evid Based Ment Health. 2005 Nov;8(4):107] </ref>. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 16:35, 20 January 2011
In complementary and alternative medicine, hypericum, also called St John's wort may have medicinal purposes.
Pharmacology
A component of hypericum, hyperforin, may act as a serotonin uptake inhibitor.[1]
Clinical purposes
Hypericum may help treat mild depression.[2]
One randomized controlled trial found no benefit[3], whereas a subsequent trial using a higher dose of hypericum (900 mg/day hypericum extract three times a day) found benefit[4].
References
- ↑ Schulte-Löbbert S, Holoubek G, Müller WE, Schubert-Zsilavecz M, Wurglics M (2004). "Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.". J Pharm Pharmacol 56 (6): 813-8. DOI:10.1211/0022357023493. PMID 15231048. Research Blogging.
- ↑ Geddes J, Butler R, Hatcher S, Cipriani A, Price J, Carney S et al. (2006). "Depression in adults.". Clin Evid (15): 1366-406. PMID 16973054. [e]
- ↑ Hypericum Depression Trial Study Group (2002). "Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.". JAMA 287 (14): 1807-14. PMID 11939866. [e] Review in: Evid Based Ment Health. 2002 Nov;5(4):111
- ↑ Szegedi A, Kohnen R, Dienel A, Kieser M (2005). "Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine.". BMJ 330 (7490): 503. DOI:10.1136/bmj.38356.655266.82. PMID 15708844. PMC PMC552808. Research Blogging. Review in: Evid Based Ment Health. 2005 Nov;8(4):107