Menopause: Difference between revisions
Jump to navigation
Jump to search
imported>Robert Badgett No edit summary |
imported>Robert Badgett |
||
| Line 5: | Line 5: | ||
==Treatment== | ==Treatment== | ||
[[Estrogen replacement therapy]] may help. | |||
[[Second-generation antidepressant]]s ([[paroxetine]], [[venlafaxine]], [[fluoxetine]]) and [[gabapentin]] may reduce [[hot flash]]es according to meta-analysis.<ref name="pmid16670414">{{cite journal| author=Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J et al.| title=Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. | journal=JAMA | year= 2006 | volume= 295 | issue= 17 | pages= 2057-71 | pmid=16670414 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16670414 | doi=10.1001/jama.295.17.2057 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17152139 Review in: J Fam Pract. 2006 Aug;55(8):662] </ref><ref name="pmid19332723">{{cite journal| author=Loprinzi CL, Sloan J, Stearns V, Slack R, Iyengar M, Diekmann B et al.| title=Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis. | journal=J Clin Oncol | year= 2009 | volume= 27 | issue= 17 | pages= 2831-7 | pmid=19332723 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19332723 | doi=10.1200/JCO.2008.19.6253 | pmc=PMC2698018 }} </ref> A more recent [[randomized controlled trial]]s report benefit from [[escitalopram]] which reduces the number of hot flashes per day by about one compared to placebo.<ref name="pmid21245182">{{cite journal| author=Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H et al.| title=Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. | journal=JAMA | year= 2011 | volume= 305 | issue= 3 | pages= 267-74 | pmid=21245182 | doi=10.1001/jama.2010.2016 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21245182 }} </ref>. | [[Second-generation antidepressant]]s ([[paroxetine]], [[venlafaxine]], [[fluoxetine]]) and [[gabapentin]] may reduce [[hot flash]]es according to meta-analysis.<ref name="pmid16670414">{{cite journal| author=Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J et al.| title=Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. | journal=JAMA | year= 2006 | volume= 295 | issue= 17 | pages= 2057-71 | pmid=16670414 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16670414 | doi=10.1001/jama.295.17.2057 }} [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17152139 Review in: J Fam Pract. 2006 Aug;55(8):662] </ref><ref name="pmid19332723">{{cite journal| author=Loprinzi CL, Sloan J, Stearns V, Slack R, Iyengar M, Diekmann B et al.| title=Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis. | journal=J Clin Oncol | year= 2009 | volume= 27 | issue= 17 | pages= 2831-7 | pmid=19332723 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19332723 | doi=10.1200/JCO.2008.19.6253 | pmc=PMC2698018 }} </ref> A more recent [[randomized controlled trial]]s report benefit from [[escitalopram]] which reduces the number of hot flashes per day by about one compared to placebo.<ref name="pmid21245182">{{cite journal| author=Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H et al.| title=Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial. | journal=JAMA | year= 2011 | volume= 305 | issue= 3 | pages= 267-74 | pmid=21245182 | doi=10.1001/jama.2010.2016 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21245182 }} </ref>. | ||
Revision as of 07:48, 5 July 2011
Menopause is defined as "the permanent cessation of menses (menstruation)."[1]
The typical duration of symptoms is 4 years[2]; although a uncontrolled study suggests a much longer duration[3].
Treatment
Estrogen replacement therapy may help.
Second-generation antidepressants (paroxetine, venlafaxine, fluoxetine) and gabapentin may reduce hot flashes according to meta-analysis.[4][5] A more recent randomized controlled trials report benefit from escitalopram which reduces the number of hot flashes per day by about one compared to placebo.[6].
Hot flushes can be reduced in some women with as little as 0.014 mg of 17--estradiol in a daily transdermal patch.[7]
References
- ↑ National Library of Medicine. Menopause. Retrieved on 2007-12-21.
- ↑ Politi MC, Schleinitz MD, Col NF (September 2008). "Revisiting the duration of vasomotor symptoms of menopause: a meta-analysis". J Gen Intern Med 23 (9): 1507–13. DOI:10.1007/s11606-008-0655-4. PMID 18521690. Research Blogging.
- ↑ Schjerning Olsen AM, Fosbøl EL, Lindhardsen J, Folke F, Charlot M, Selmer C et al. (2011). "Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction: A Nationwide Cohort Study.". Circulation. DOI:10.1161/CIRCULATIONAHA.110.004671. PMID 21555710. Research Blogging.
- ↑ Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J et al. (2006). "Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.". JAMA 295 (17): 2057-71. DOI:10.1001/jama.295.17.2057. PMID 16670414. Research Blogging. Review in: J Fam Pract. 2006 Aug;55(8):662
- ↑ Loprinzi CL, Sloan J, Stearns V, Slack R, Iyengar M, Diekmann B et al. (2009). "Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis.". J Clin Oncol 27 (17): 2831-7. DOI:10.1200/JCO.2008.19.6253. PMID 19332723. PMC PMC2698018. Research Blogging.
- ↑ Freeman EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H et al. (2011). "Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.". JAMA 305 (3): 267-74. DOI:10.1001/jama.2010.2016. PMID 21245182. Research Blogging.
- ↑ Bachmann GA, Schaefers M, Uddin A, Utian WH (2007). "Lowest effective transdermal 17beta-estradiol dose for relief of hot flushes in postmenopausal women: a randomized controlled trial". Obstet Gynecol 110 (4): 771–9. DOI:10.1097/01.AOG.0000284450.51264.31. PMID 17906008. Research Blogging.