Na,K-ATPase: Difference between revisions
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The '''Na,K-ATPase''', which is commonly know as the "'''sodium-potassium pump'''" or, more colloquially, the "'''sodium pump'''", is the protein which ensures that the cells keep their resting potential, by pumping sodium out of cells and potassium inside cells. While mammalian cells spend the most of their "currency", ATP (adenosine triphoshate), for the building of protein (25 to 30%), the second most important expenditure is for pumping sodium out, and potassium in (generally between 19 and 28%).<ref name="pmid9234964">{{cite journal |author=Rolfe DF, Brown GC |title=Cellular energy utilization and molecular origin of standard metabolic rate in mammals |journal=Physiol. Rev. |volume=77 |issue=3 |pages=731–58 |year=1997 |pmid=9234964 |doi=}}</ref> In the brain, however, the percentage of the cell's "budget" devoted to the sodium-potassium pump averages 50 %, with grey matter requiring more, and white matter demanding less, than 50 %.<ref name="pmid11598490">{{cite journal |author=Attwell D, Laughlin SB |title=An energy budget for signaling in the grey matter of the brain |journal=J. Cereb. Blood Flow Metab. |volume=21 |issue=10 |pages=1133–45 |year=2001 |pmid=11598490 |doi=10.1097/00004647-200110000-00001 |url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10466143}} ''see page 1142, left''.</ref> | The '''Na,K-ATPase''', which is commonly know as the "'''sodium-potassium pump'''" or, more colloquially, the "'''sodium pump'''", is the protein which ensures that the cells keep their resting potential, by pumping sodium out of cells and potassium inside cells. While mammalian cells spend the most of their "currency", ATP ([[adenosine triphoshate]]), for the building of protein (25 to 30%), the second most important expenditure is for pumping sodium out, and potassium in (generally between 19 and 28%).<ref name="pmid9234964">{{cite journal |author=Rolfe DF, Brown GC |title=Cellular energy utilization and molecular origin of standard metabolic rate in mammals |journal=Physiol. Rev. |volume=77 |issue=3 |pages=731–58 |year=1997 |pmid=9234964 |doi=}}</ref> In the brain, however, the percentage of the cell's "budget" devoted to the sodium-potassium pump averages 50 %, with grey matter requiring more, and white matter demanding less, than 50 %.<ref name="pmid11598490">{{cite journal |author=Attwell D, Laughlin SB |title=An energy budget for signaling in the grey matter of the brain |journal=J. Cereb. Blood Flow Metab. |volume=21 |issue=10 |pages=1133–45 |year=2001 |pmid=11598490 |doi=10.1097/00004647-200110000-00001 |url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=10466143}} ''see page 1142, left''.</ref> | ||
== References == | == References == | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:53, 27 June 2008
The Na,K-ATPase, which is commonly know as the "sodium-potassium pump" or, more colloquially, the "sodium pump", is the protein which ensures that the cells keep their resting potential, by pumping sodium out of cells and potassium inside cells. While mammalian cells spend the most of their "currency", ATP (adenosine triphoshate), for the building of protein (25 to 30%), the second most important expenditure is for pumping sodium out, and potassium in (generally between 19 and 28%).[1] In the brain, however, the percentage of the cell's "budget" devoted to the sodium-potassium pump averages 50 %, with grey matter requiring more, and white matter demanding less, than 50 %.[2]
References
- ↑ Rolfe DF, Brown GC (1997). "Cellular energy utilization and molecular origin of standard metabolic rate in mammals". Physiol. Rev. 77 (3): 731–58. PMID 9234964. [e]
- ↑ Attwell D, Laughlin SB (2001). "An energy budget for signaling in the grey matter of the brain". J. Cereb. Blood Flow Metab. 21 (10): 1133–45. DOI:10.1097/00004647-200110000-00001. PMID 11598490. Research Blogging. see page 1142, left.