New Delhi metallo-beta-lactamase-1

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New Delhi metallo-beta-lactamase-1 enzyme confers bacterial resistance to antibiotics of the carbepenem class, often considered "last resort" drugs for multidrug resistant bacteria.[1] The gene to manufacture it can be horizontally transferred among different species of pathogenic bacteria.

First reported in Klebsiella pneumoniae, it has been reported in Acinetobacter baumanae, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, and Morganella morganii. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.[2]

References

  1. ↑ Krishna B (2010 [cited 2010 Sep 14]), "New Delhi metallo-beta-lactamases: A wake-up call for microbiologists", Indian J Med Microbiol [serial online] 28: 265-6.
  2. ↑ "NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02)", ProMED Emerging Disease Report, International Society for Infectious Diseases, 14 September 2010
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