Protein folding

Proteins are large molecules composed of smaller constituents called amino acids. They are ubiquitous and essential for all life. The 3-dimensional structure and the function of a protein are intimately related. The process by which a protein achieves a final structure is referred to as protein folding.

History of Protein Folding as a Field

C. Anfinsen. K. Dill. Etc.

Proposed Mechanisms

Hydrophobic Collapse. Nucleation-condensation. Viscosity-Collision. Etc.

Thermodynamics

Folding Funnel/Energy Landscapes. Etc.

Chaperones

Chaperones make up a unique class of proteins which can aid in the proper folding of other proteins. For more information, see Chaperone Proteins.

Related Diseases and Disorders

Alzheimer's. Prion Disease(s) (Transmissable Spongiform Encephalopathies). Creutzfeldt-Jakob Disease. Parkinson's Disease. Huntington's Disease. Amyotrophic Lateral Sclerosis.