Reserpine: Difference between revisions
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In [[pharmacology]], '''reserpine''' is "an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of [[norepinephrine]] into storage vesicles resulting in depletion of catecholamines and [[serotonin]] from central and peripheral axon terminals. It has been used as an [[antihypertensive agent|antihypertensive]] and an [[antipsychotic agent|antipsychotic]] as well as a research tool..."<ref>{{MeSH}}</ref> | In [[pharmacology]], '''reserpine''' is "an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of [[norepinephrine]] into storage vesicles resulting in depletion of catecholamines and [[serotonin]] from central and peripheral axon terminals. It has been used as an [[antihypertensive agent|antihypertensive]] and an [[antipsychotic agent|antipsychotic]] as well as a research tool..."<ref>{{MeSH}}</ref> | ||
==Efficacy== | ), ==Efficacy== | ||
===Hypertension=== | ===Hypertension=== | ||
Reserpine can lower the systolic blood pressure by about 8 mm Hg in patients with [[hypertension]].<ref name="pmid19821434">{{cite journal| author=Shamon SD, Perez MI| title=Blood pressure lowering efficacy of reserpine for primary hypertension. | journal=Cochrane Database Syst Rev | year= 2009 | volume= | issue= 4 | pages= CD007655 | pmid=19821434 | Reserpine can lower the systolic blood pressure by about 8 mm Hg in patients with [[hypertension]].<ref name="pmid19821434">{{cite journal| author=Shamon SD, Perez MI| title=Blood pressure lowering efficacy of reserpine for primary hypertension. | journal=Cochrane Database Syst Rev | year= 2009 | volume= | issue= 4 | pages= CD007655 | pmid=19821434 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19821434 | doi=10.1002/14651858.CD007655.pub2 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>- | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19821434 | doi=10.1002/14651858.CD007655.pub2 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | ||
Reserpine was a component in many major trials of treating hypertension such as the Hypertension Detection and Follow-Up Program ( Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 HDFP)<ref name="pmid490882">{{cite journal| author=| title=Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group. | journal=JAMA | year= 1979 | volume= 242 | issue= 23 | pages= 2562-71 | pmid=490882 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=490882 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref><ref name="pmid490883">{{cite journal| author=| title=Five-year findings of the hypertension detection and follow-up program. II. Mortality by race-sex and age. Hypertension Detection and Follow-up Program Cooperative Group. | journal=JAMA | year= 1979 | volume= 242 | issue= 23 | pages= 2572-7 | pmid=490883 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=490883 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>, Veterans Administrative Cooperative Study Group in Anti-hypertensive Agents<ref name="pmid323525">{{cite journal| author=| title=Propranolol in the treatment of essential hypertension. | journal=JAMA | year= 1977 | volume= 237 | issue= 21 | pages= 2303-10 | pmid=323525 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=323525 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> and the Systolic Hypertension in the Elderly Program (SHEP)<ref name="pmid10904510">{{cite journal| author=Perry HM, Davis BR, Price TR, Applegate WB, Fields WS, Guralnik JM et al.| title=Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP). | journal=JAMA | year= 2000 | volume= 284 | issue= 4 | pages= 465-71 | pmid=10904510 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=10904510 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref><ref name="pmid8968014">{{cite journal| author=Curb JD, Pressel SL, Cutler JA, Savage PJ, Applegate WB, Black H et al.| title=Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group. | journal=JAMA | year= 1996 | volume= 276 | issue= 23 | pages= 1886-92 | pmid=8968014 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8968014 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>. | |||
==Adverse effects== | |||
In a review of 691 patients in seven studies, McMahon found that 5% of patients discontinued reserpine because of adverse effects. <ref name="isbn0879931086">{{Cite book |author=McMahon FG | title = Management of essential hypertension | date = 1978 | publisher = Futura Pub. Co. | location = Mount Kisco, N.Y. | isbn = 0-87993-108-6 | pages = |isbn=0879931086 }}</ref> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 05:50, 4 November 2009
In pharmacology, reserpine is "an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool..."[1]
), ==Efficacy==
Hypertension
Reserpine can lower the systolic blood pressure by about 8 mm Hg in patients with hypertension.[2]
Reserpine was a component in many major trials of treating hypertension such as the Hypertension Detection and Follow-Up Program ( Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 HDFP)[3][4], Veterans Administrative Cooperative Study Group in Anti-hypertensive Agents[5] and the Systolic Hypertension in the Elderly Program (SHEP)[6][7].
Adverse effects
In a review of 691 patients in seven studies, McMahon found that 5% of patients discontinued reserpine because of adverse effects. [8]
References
- ↑ Anonymous (2024), Reserpine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Shamon SD, Perez MI (2009). "Blood pressure lowering efficacy of reserpine for primary hypertension.". Cochrane Database Syst Rev (4): CD007655. DOI:10.1002/14651858.CD007655.pub2. PMID 19821434. Research Blogging.
- ↑ (1979) "Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group.". JAMA 242 (23): 2562-71. PMID 490882.
- ↑ (1979) "Five-year findings of the hypertension detection and follow-up program. II. Mortality by race-sex and age. Hypertension Detection and Follow-up Program Cooperative Group.". JAMA 242 (23): 2572-7. PMID 490883.
- ↑ (1977) "Propranolol in the treatment of essential hypertension.". JAMA 237 (21): 2303-10. PMID 323525.
- ↑ Perry HM, Davis BR, Price TR, Applegate WB, Fields WS, Guralnik JM et al. (2000). "Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP).". JAMA 284 (4): 465-71. PMID 10904510.
- ↑ Curb JD, Pressel SL, Cutler JA, Savage PJ, Applegate WB, Black H et al. (1996). "Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group.". JAMA 276 (23): 1886-92. PMID 8968014.
- ↑ McMahon FG (1978). Management of essential hypertension. Mount Kisco, N.Y.: Futura Pub. Co.. ISBN 0879931086.