Serotonin syndrome: Difference between revisions
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imported>Robert Badgett (Added "Notable cases" which I had written earlier at WP) |
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'''Serotonin syndrome''' is an "adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the [[Biogenic amine receptor|serotonin 1A receptor]]."<ref>{{MeSH}}</ref> | '''Serotonin syndrome''' is an "adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the [[Biogenic amine receptor|serotonin 1A receptor]]."<ref>{{MeSH}}</ref><ref name="pmid15784664">{{cite journal |author=Boyer EW, Shannon M |title=The serotonin syndrome |journal=N. Engl. J. Med. |volume=352 |issue=11 |pages=1112-20 |year=2005 |pmid=15784664 |doi=10.1056/NEJMra041867|url=http://content.nejm.org/cgi/content/full/352/11/1112}}</ref> | ||
==Notable cases== | |||
The death of [[Libby Zion]] was due to serotonin syndrome caused by a combination of [[meperidine]] and [[phenelzine]].<ref name="pmid15784664"/> This case had a profound impact on graduate medical education and residency work hour limitations.<ref name="pmid9757752">{{cite journal |author=Brensilver JM, Smith L, Lyttle CS |title=Impact of the Libby Zion case on graduate medical education in internal medicine |journal=Mt. Sinai J. Med. |volume=65 |issue=4 |pages=296-300 |year=1998 |pmid=9757752 |doi=}}</ref> | |||
==References== | ==References== | ||
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==See also== | ==See also== | ||
* [[Neuroleptic malignant syndrome]] | * [[Neuroleptic malignant syndrome]] | ||
* [[Malignant hyperthermia]] | |||
Revision as of 10:10, 2 April 2008
Serotonin syndrome is an "adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor."[1][2]
Notable cases
The death of Libby Zion was due to serotonin syndrome caused by a combination of meperidine and phenelzine.[2] This case had a profound impact on graduate medical education and residency work hour limitations.[3]
References
- ↑ Anonymous (2024), Serotonin syndrome (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 Boyer EW, Shannon M (2005). "The serotonin syndrome". N. Engl. J. Med. 352 (11): 1112-20. DOI:10.1056/NEJMra041867. PMID 15784664. Research Blogging.
- ↑ Brensilver JM, Smith L, Lyttle CS (1998). "Impact of the Libby Zion case on graduate medical education in internal medicine". Mt. Sinai J. Med. 65 (4): 296-300. PMID 9757752. [e]