Talk:Physiology

This article did not exist after the initial unforking from Wikipedia. I am beginning to write it. Please join me!Nancy Sculerati MD 17:47, 26 January 2007 (CST)

Ok, I'll join in a lot more once I see a structure or outline. -Tom Kelly (Talk) 17:48, 26 January 2007 (CST)

redirects

How do you do a redirect so pathophysiology and physiopathology don't have 2 articles started - they should just be the same thing, but I want to link them both. -Tom Kelly (Talk) 18:04, 26 January 2007 (CST)

Pathophysiology, physiopathology

I don't know. I have never heard the term physiopathology. I am placing the word bank below - it's a great idea -but it should be in discussion.

Yeah, I just figured that discussions never get erased and we could just edit things out as we went along. Also by having many == == you can edit one part without interrupting the other persons edits.

check stedmans for the syn. "pathologic physiology. that part of the science of disease concerned with disordered function, as distinguished from anatomic lesions. SYN: physiopathology." -Stedmans electronic medical dictionary.

It's just my ignorance! :-) but it could also be a term that is not used much...Nancy Sculerati MD 18:22, 26 January 2007 (CST)

word (and idea) bank for this article

general physiology hominal physiology comparative physiology

biochemistry / biochemical components (make-up)

make link to Physiology as a degree/major/field of study

major systems studied. renal physiology,

These days a common approach is to deal with physiology by levels:

• molecular physiology
• cellular physiology
• systems physiology

the term integrative physiology is sometimes used (as in the Centre to which I belong) to describe approaches that try to link across levels. Historically, physiology embraced many subjects like biochemistry, pharmacology and immunology that are now regarded as quite separate disciplines. For some, what still distinguishes physiology is the concept of physiological relevance - i.e. the need to show how an observed mechanism or phenomenon is involved in the normal function of the organism involved. Thus a pharmacological response merely demonstrates the presence of functional receptors, a physiological response entails showing the involvement of an endogenous ligand in an effect that has demonstrably adaptive consequences. A major late offshoot of physiology is biophysics. Major names in the history of physiology in the first half of the 20th century might include Hodgkin and Huxley (physiology of the nervous impulse), Starling (endocrine scretions), Ringer (frog heart), Katz (neuromuscular junction), Adrian (nerve impulses), Sharpey-Shafer (adrenals and other endocrine systems), Sherrington (spinal reflexes), Dale (transmitter release), Eccles (synapses), Geoffrey Harris (neuroendocrine systems) (a very UK-centric list of our glory days), but also Nernst, Cajal, Banting and Best, Howard Florey....Gareth Leng 18:35, 26 January 2007 (CST)

Plan??

Aim: An article written to be understood by the intelligent lay reader. An article that places physiology in context among related biological disciplies, i;e; which distinguishes the discipline from others with which it is easily confused. An article that displays a purposefully chosen selection of examples to illustrate the sorts of things that comprise physiology; an article that explains the historical origins and development of physiology as well as illustrating contemporary approaches. An article that gives access to further resources for school students, undergraduates and teachers especially; An article that should have relatively few references itself, as the content should largely stand on our authority as editors, should not contain anything in any serious dispute, and is simply a gateway tomore specialised articles;

• Lead, a Brief summary of about 300 words giving a clear, natural language explanation of what physiology is;
• Introduction, overview, molecules to systems and integrative physiology

Separate sections for each, focused around a carefully chosen illustrative example?

• Molecular physiology; the context here is the post genomc drive to understand the physiological functions of the genes in the genome; an important elementin that is understanding the regulation of gene expression, and measuring changes in gene expression in different phydiological states. I think we'd be looking for examples of the physiological regulation of gene expression to illustrate this - perhaps from microarray technology, (though I'm not a fan, but so what)I,d suggest the focus here should be on the new technologies, proteomics etc

• Cellular physiology; I guess one of the most influential classic examples here is the work of Hogkin and Huxley to explain the propogation of the nervous impulse, published in The Journal of Physiology in the 50s and which won them the Nobel Prize. Muscle contaction is another great example,or transduction mechanisms in sensory cells

• Systems physiology; perhaps cardiovascular physiology? Or a reflex, the milk ejection reflex is my personal fovourite reflex of all time, maybe talk about two, e.g. spinal reflexes (Sherrington) and an endocrine reflex?

• Integrative physiology; here perhaps we need a modern example of how transgenics is used to elucidate the physiological function of a gene; perhaps the story of leptin is perhaps a good example. Recently perhaps nitric oxide?

• History; well its been an everbranching tree, there,s a rich source here and probably best to mention just a very few.

• Links to journals, societies, Wellcome Trust sources, particularly where they offer electronically available material for public understanding.

Anyway, these are my suggestions not my prescription. Gareth Leng 11:10, 27 January 2007 (CST)

Well, I'm prescribing it - as our Tentative Plan. Let's start! :-) Nancy Sculerati MD 11:15, 27 January 2007 (CST)

Paradigm

Lets take a specific example that we can follow from molecular to systems- like the movement of the body with skeletal muscle. If you can think of a better one, I'm game. Nancy Sculerati MD 13:02, 30 January 2007 (CST)

How about the movement of water to the top of a tree? :) But i do think the muscle idea is a good one. Works at all scales. Chris Day (Talk) 13:08, 30 January 2007 (CST)