Tipranavir

From Citizendium
Revision as of 12:34, 29 January 2008 by imported>David E. Volk (New page: {{subpages}} right|thumb|250px|{{#ifexist:Template:Tipranavir structure.jpg/credit|{{Tipranavir structure.jpg/credit}}<br/>|}}Tipranavir '''Tipranavir'...)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Tipranavir

Tipranavir ('TPV), sold under the brand name Aptivus®, is a nonpeptidic protease inhibitor drug used to treat HIV/AIDS in combination with ritonavir. It is used for patients with extensive previous treatment of those infected with HIV strains that have multiple protease inhibitor resistance. Tipranavir blocks the function of protease enzymes sothat the Gag and Gag-Pol polyprotein cannot be cleaved into individual active proteins, thus blocking the formation of infectious mature viral particles. Such inhibitors all almost always used in a combination therapy with other anti-HIV drugs.


Its IUPAC chemical name is Name N-[3-[(1R)-1-[(6R)-2-hydroxy-4-oxo-6-(2-phenylethyl)-6-propyl-5H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide and its chemical formula is C31H33F3N2O5S.

External Links