William Harvey/Bibliography

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A list of key readings about William Harvey.
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Works by William Harvey

  • Harvey W. (1961; originally written 1616-?) Lectures on the Whole of Anatomy: An Annotated Translation of Prelectiones Anatomiae Universalis. C. D. O'Malley - transltr, F. N. L. Poynter - transltr, K. F. Russell - transltr. University of California Press. Berkeley, CA.
    • From the Introduction  The circumstances attending the production of these lecture notes have never been discussed, but the more closely they are investigated the clearer does it become that many features of them which have been taken for granted are still open to question. They are certainly notes that Harvey prepared for his Lumleian lectures, and, judging by their scope, by the research into the literature which is revealed in the citations, and by the personal observations briefly referred to, Harvey must have spent much time in compiling them.

About William Harvey

On the evolution of the mammalian heart

  • Koshiba-Takeuchi K, Mori AD, Kaynak L, Cebra-Thomas J, Tatyana T, Georges RO, Latham S, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG. (2009) Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature 461:95-98 (3 September 2009) | [1]
    • AbstractThe emergence of terrestrial life witnessed the need for more sophisticated circulatory systems. This has evolved in birds, mammals and crocodilians into complete septation of the heart into left and right sides, allowing separate pulmonary and systemic circulatory systems, a key requirement for the evolution of endothermy1, 2, 3. However, the evolution of the amniote heart is poorly understood. Reptilian hearts have been the subject of debate in the context of the evolution of cardiac septation: do they possess a single ventricular chamber or two incompletely septated ventricles4, 5, 6, 7? Here we examine heart development in the red-eared slider turtle, Trachemys scripta elegans (a chelonian), and the green anole, Anolis carolinensis (a squamate), focusing on gene expression in the developing ventricles. Both reptiles initially form a ventricular chamber that homogenously expresses the T-box transcription factor gene Tbx5. In contrast, in birds and mammals, Tbx5 is restricted to left ventricle precursors8, 9. In later stages, Tbx5 expression in the turtle (but not anole) heart is gradually restricted to a distinct left ventricle, forming a left–right gradient. This suggests that Tbx5 expression was refined during evolution to pattern the ventricles. In support of this hypothesis, we show that loss of Tbx5 in the mouse ventricle results in a single chamber lacking distinct identity, indicating a requirement for Tbx5 in septation. Importantly, misexpression of Tbx5 throughout the developing myocardium to mimic the reptilian expression pattern also results in a single mispatterned ventricular chamber lacking septation. Thus ventricular septation is established by a steep and correctly positioned Tbx5 gradient. Our findings provide a molecular mechanism for the evolution of the amniote ventricle, and support the concept that altered expression of developmental regulators is a key mechanism of vertebrate evolution.
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