Chlorthalidone

From Citizendium, the Citizens' Compendium

Chlorthalidone (pronounced: (klor thal' i done) ^MedMaster) is a medication used for treating hypertension in humans. Chlorthalidone is a thiazide-like diuretic. Compared to hydrochlorothiazide, chlorthalidone is more potent and has a longer duration of action.^[1][2] This may result in improved outcomes.^[3]

Contents 1 Effectiveness 2 Indications 2.1 United States 3 References 4 External links

Effectiveness

Chlorthalidone reduced cardiovascular disease in the ALLHAT randomized controlled trial and was more effective than amlodipine and lisinopril.^[4]

Indications

United States

Indications according to the United States Food and Drug Administration are:^[5]

• Diuretics such as chlorthalidone are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
• Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.
• Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

References

1. ↑ Carter BL, Ernst ME, Cohen JD (January 2004). Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability. Hypertension 43 (1): 4–9. DOI:10.1161/01.HYP.0000103632.19915.0E. PMID 14638621.
2. ↑ Ernst ME, Carter BL, Goerdt CJ, et al (March 2006). Comparative antihypertensive effects of hydrochlorothiazide and chlorthalidone on ambulatory and office blood pressure. Hypertension 47 (3): 352–8. DOI:10.1161/01.HYP.0000203309.07140.d3. PMID 16432050.
3. ↑ (November 1990) "Mortality after 10 1/2 years for hypertensive participants in the Multiple Risk Factor Intervention Trial". Circulation 82 (5): 1616–28. PMID 2225366.
4. ↑ (December 2002) Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA : the journal of the American Medical Association 288 (23): 2981–97. PMID 12479763.
5. ↑ The most up-to-date information about Chlorthalidone and other drugs can be found at the following sites.
   • Chlorthalidone - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
   • Chlorthalidone - Drug information for consumers from MedMaster (U.S. National Library of Medicine).
   • Chlorthalidone - Detailed information from DrugBank.

External links

The most up-to-date information about Chlorthalidone and other drugs can be found at the following sites.

• Chlorthalidone - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Chlorthalidone - Drug information for consumers from MedMaster (U.S. National Library of Medicine).
• Chlorthalidone - Detailed information from DrugBank.