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In biochemistry, cyclooxygenase 2 is an enzyme that is "an inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and inflammation. It is the target of cox2 inhibitors." Like cyclooxygenase 1 and lipoxygenase, its substrate is arachidonic acid.
Cyclooxygenase 2 is expressed by most colorectal cancers and is associated with reduced survival.
Cyclooxygenase 2 inhibitors are medications that block the action of cyclooxygenase 2.
- ↑ Anonymous (2023), Cyclooxygenase 2 (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K (2004). "Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer.". Clin Cancer Res 10 (24): 8465-71. DOI:10.1158/1078-0432.CCR-04-0653. PMID 15623626. Research Blogging.