Mephenytoin
From Citizendium, the Citizens' Compendium
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| Uses: | anti-seizure drug | ||||||
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Mephenytoin (Mesantoin®) is an anticonvulsant medication used to treat epilepsy and it is particularly effective in tonic-clonic epilepsy . Its common chemical name is 3-methyl 5,5-phenyl-ethyl-hydantoin and its IUPAC chemical name is 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione. It has pharmacological effects similar to phenytoin and the barbiturates.
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Mechanism of action
The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.[1]
Synonyms and brand names
Synonyms
- Mephentoin
- Methyl Hydantoin
- Methylphenetoin
Brand Names
- Epiazin®
- Gerot-Epilan®
- Insulton®
- Mesdontoin®
- Mesontoin®
- Methoin®
- Metydan®
- Phenantoin®
- Sacerno®
- Sedantional®
- Sedantoin®
- Sedantoinal®
- Triantoin®
External links
The most up-to-date information about Mephenytoin and other drugs can be found at the following sites.
- Mephenytoin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Mephenytoin - Drug information for consumers from MedMaster (U.S. National Library of Medicine).
- Mephenytoin - Detailed information from DrugBank.
References
- ↑ DrugBank page for Mephenytoin. Retrieved on 062508.
