Nitrofurantoin

From Citizendium
Jump to navigation Jump to search
This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.

In medicine, nitrofurantion is an antibiotic that is a "urinary anti-infective agent effective against most Gram-positive and Gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression."[1]

Nitrofurantoin achieves good renal and urinary concentrations, but not serum good concentrations.[2]

Effectiveness

Randomized controlled trials have shown nirofurantion to be equivalent to trimethoprim-sulfamethoxazole[3] and ciprofloxacin[3][4] in treating uncomplicated urinary tract infections (cystitis).

References

  1. Anonymous (2024), Nitrofurantoin (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Pham P, Bartlett JG (2008). Nitrofurantion. Johns Hopkins Antibiotic Guide. Retrieved on 2008-10-05.
  3. 3.0 3.1 Iravani A, Klimberg I, Briefer C, Munera C, Kowalsky SF, Echols RM (March 1999). "A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection". The Journal of antimicrobial chemotherapy 43 Suppl A: 67–75. PMID 10225575[e]
  4. Gupta K, Hooton TM, Roberts PL, Stamm WE (November 2007). "Short-course nitrofurantoin for the treatment of acute uncomplicated cystitis in women". Archives of internal medicine 167 (20): 2207–12. DOI:10.1001/archinte.167.20.2207. PMID 17998493. Research Blogging.