Drug-induced liver injury: Difference between revisions
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In [[gastroenterology]] and [[pharmacology]], '''drug-induced liver injury''', also called '''drug-induced liver disease''' or '''drug-induced hepatoxocity''' is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".<ref name="pmid16481640">{{cite journal |author=Navarro VJ, Senior JR |title=Drug-related hepatotoxicity |journal=N. Engl. J. Med. |volume=354 |issue=7 |pages=731–9 |year=2006 |month=February |pmid=16481640 |doi=10.1056/NEJMra052270 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=16481640&promo=ONFLNS19 |issn=}}</ref> | In [[gastroenterology]] and [[pharmacology]], '''drug-induced liver injury''', also called '''drug-induced liver disease''' or '''drug-induced hepatoxocity''' is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".<ref name="pmid16481640">{{cite journal |author=Navarro VJ, Senior JR |title=Drug-related hepatotoxicity |journal=N. Engl. J. Med. |volume=354 |issue=7 |pages=731–9 |year=2006 |month=February |pmid=16481640 |doi=10.1056/NEJMra052270 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=16481640&promo=ONFLNS19 |issn=}}</ref> | ||
Large case series have been published. In one series, common causes include [[antibiotic]]s, [[anticonvulsant]]s, and [[psychotropic drug]]s.<ref name="pmid18955056">{{cite journal |author=Chalasani N, Fontana RJ, Bonkovsky HL, ''et al'' |title=Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States |journal=Gastroenterology |volume=135 |issue=6 |pages=1924–34, 1934.e1–4 |year=2008 |month=December |pmid=18955056 |doi=10.1053/j.gastro.2008.09.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S0016-5085(08)01674-0 |issn=}}</ref> In a second series, common causes included [[isoniazid]], sulfa antibiotics, [[nitrofurantoin]], [[phenytoin]], [[Non-steroidal anti-inflammatory agent]]s, [[hydroxymethylglutaryl-coenzyme A reductase inhibitor]]s (statins), propylthiouracil, [[complementary and alternative medicine]]s, and illicit drugs.<ref name="pmid20949552">{{cite journal| author=Reuben A, Koch DG, Lee WM, Acute Liver Failure Study Group| title=Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. | journal=Hepatology | year= 2010 | volume= 52 | issue= 6 | pages= 2065-76 | pmid=20949552 | doi=10.1002/hep.23937 | pmc= | url= }} </ref> | |||
==Patterns of liver injury== | ==Patterns of liver injury== | ||
Latest revision as of 09:56, 27 January 2011
In gastroenterology and pharmacology, drug-induced liver injury, also called drug-induced liver disease or drug-induced hepatoxocity is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".[1]
Large case series have been published. In one series, common causes include antibiotics, anticonvulsants, and psychotropic drugs.[2] In a second series, common causes included isoniazid, sulfa antibiotics, nitrofurantoin, phenytoin, Non-steroidal anti-inflammatory agents, hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins), propylthiouracil, complementary and alternative medicines, and illicit drugs.[3]
Patterns of liver injury
Hepatocellular
Cholestatic
Mixed
References
- ↑ Navarro VJ, Senior JR (February 2006). "Drug-related hepatotoxicity". N. Engl. J. Med. 354 (7): 731–9. DOI:10.1056/NEJMra052270. PMID 16481640. Research Blogging.
- ↑ Chalasani N, Fontana RJ, Bonkovsky HL, et al (December 2008). "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States". Gastroenterology 135 (6): 1924–34, 1934.e1–4. DOI:10.1053/j.gastro.2008.09.011. PMID 18955056. Research Blogging.
- ↑ Reuben A, Koch DG, Lee WM, Acute Liver Failure Study Group (2010). "Drug-induced acute liver failure: results of a U.S. multicenter, prospective study.". Hepatology 52 (6): 2065-76. DOI:10.1002/hep.23937. PMID 20949552. Research Blogging.