Beta-2 adrenergic receptor: Difference between revisions

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In [[medicine]] and [[physiology]], '''beta-2 adrenergic receptors''', or '''β-2 adrenergic receptors''',  are  [[cell surface receptor]]s of the [[G-protein-coupled receptor]] type that are in the [[sympathetic nervous system]]. Beta-2 adrenergic receptors are a "subclass of [[beta-adrenergic receptor]]s (receptors, adrenergic,  beta). Beta-2 Adrenergic receptors are more sensitive to [[epinephrine]] than to [[norepinephrine]] and have a high affinity for the agonist [[terbutaline]]. They are widespread, with  clinically important roles in skeletal muscle, liver, and vascular,  bronchial, gastrointestinal, and genitourinary smooth muscle."<ref  name="MeSH-Beta-2">{{MeSH}}</ref> Their functions  include ''vasodilation''.
In [[medicine]] and [[physiology]], '''beta-2 adrenergic receptors''', or '''β-2 adrenergic receptors''',  are  [[cell surface receptor]]s of the [[G-protein-coupled receptor]] type that are in the [[sympathetic nervous system]]. Beta-2 adrenergic receptors are a "subclass of beta-[[adrenergic receptor]]s (receptors, adrenergic,  beta). Beta-2 Adrenergic receptors are more sensitive to [[epinephrine]] than to [[norepinephrine]] and have a high affinity for the agonist [[terbutaline]]. They are widespread, with  clinically important roles in skeletal muscle, liver, and vascular,  bronchial, gastrointestinal, and genitourinary smooth muscle."<ref  name="MeSH-Beta-2">{{MeSH}}</ref> Their functions  include ''vasodilation''.


After binding, [[signal transduction]] activates the [[second messenger system]]s adenyl cyclase-[[cyclic AMP]] primarily and also [[cyclic GMP]] which then activates [[protein kinase]]s.
After binding, [[signal transduction]] activates the [[second messenger system]]s adenyl cyclase-[[cyclic AMP]] primarily and also [[cyclic GMP]] which then activates [[protein kinase]]s.

Revision as of 12:30, 30 March 2010

In medicine and physiology, beta-2 adrenergic receptors, or β-2 adrenergic receptors, are cell surface receptors of the G-protein-coupled receptor type that are in the sympathetic nervous system. Beta-2 adrenergic receptors are a "subclass of beta-adrenergic receptors (receptors, adrenergic, beta). Beta-2 Adrenergic receptors are more sensitive to epinephrine than to norepinephrine and have a high affinity for the agonist terbutaline. They are widespread, with clinically important roles in skeletal muscle, liver, and vascular, bronchial, gastrointestinal, and genitourinary smooth muscle."[1] Their functions include vasodilation.

After binding, signal transduction activates the second messenger systems adenyl cyclase-cyclic AMP primarily and also cyclic GMP which then activates protein kinases.

Adrenergic beta-agonists, such as terbutaline, are used to treat asthma by preventing bronchoconstriction.

References