Metabolic syndrome: Difference between revisions
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imported>Pierre-Alain Gouanvic (New page: The metabolic syndrome is defined by the World Health Organisation using the following criteria : * Insulin resistance, identified by '''one''' of the following: ** [[Type 2 diabetes...) |
imported>Pierre-Alain Gouanvic (Definition from the WHO; ref: consensus statement; original ref, on the insulin resistance syndromes put in context) |
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The '''metabolic syndrome''', also known as the dysmetabolic syndrome, or metabolic syndrome X, is a major public health concern worlwide. The growing [[obesity]] epidemic is its most noticeable effect,<ref>{{cite web |url=http://abcnews.go.com/Health/Diet/wireStory?id=3761598 |title=ABC News: The World Is Getting Rounder |accessdate=2007-11-17 |format= |work=}}</ref> but the metabolic syndrome can be present in the absence of frank obesity. Almost one fourth of Americans have metabolic syndrome, and the proportion keeps raising.<ref>{{cite web |url=http://www.nhlbi.nih.gov/health/dci/Diseases/ms/ms_whatis.html |title=What Is Metabolic Syndrome? |accessdate=2007-11-17 |format= |work=}}</ref> | |||
The metabolic syndrome is defined by the World Health Organisation using the following criteria : | The metabolic syndrome is defined by the World Health Organisation using the following criteria : | ||
* [[Insulin resistance]], identified by '''one''' of the following: | * [[Insulin resistance]], identified by '''one''' of the following: | ||
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** Urinary albumin excretion rate ≥20μmg/g or albumin: creatinine ratio ≥30 mg/g.<ref name="pmid14766739">{{cite journal |author=Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C |title=Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue=2 |pages=e13–8 |year=2004 |pmid=14766739 |doi=10.1161/01.ATV.0000111245.75752.C6}}</ref> | ** Urinary albumin excretion rate ≥20μmg/g or albumin: creatinine ratio ≥30 mg/g.<ref name="pmid14766739">{{cite journal |author=Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C |title=Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue=2 |pages=e13–8 |year=2004 |pmid=14766739 |doi=10.1161/01.ATV.0000111245.75752.C6}}</ref> | ||
The | The metabolic syndrome is thus a cluster of risk factors for diabetes and cardiovascular diseases. The syndrome includes proinflammatory and prothrombotic features.<ref name="pmid14766739"/> | ||
The metabolic syndrome could also promote the development of [[Cancer|cancer]], [[polycystic ovary syndrome|polycystic ovary syndrome]] (PCOS), and nonalcoholic fatty liver disease".<ref name="pmid16460269">{{cite journal |author=Biddinger SB, Kahn CR |title=From mice to men: insights into the insulin resistance syndromes |journal=Annu. Rev. Physiol. |volume=68 |issue= |pages=123–58 |year=2006 |pmid=16460269 |doi=10.1146/annurev.physiol.68.040104.124723}}</ref> | |||
== References == | == References == | ||
<references /> | <references /> | ||
Revision as of 04:21, 17 November 2007
The metabolic syndrome, also known as the dysmetabolic syndrome, or metabolic syndrome X, is a major public health concern worlwide. The growing obesity epidemic is its most noticeable effect,[1] but the metabolic syndrome can be present in the absence of frank obesity. Almost one fourth of Americans have metabolic syndrome, and the proportion keeps raising.[2]
The metabolic syndrome is defined by the World Health Organisation using the following criteria :
- Insulin resistance, identified by one of the following:
- Type 2 diabetes
- Impaired fasting glucose
- Impaired glucose tolerance
- or, for those with normal fasting glucose levels (<110mg/dL), glucose uptake below the lowest quartile for background population under investigation under hyperinsulinemic, euglycemic conditions
- in conjunction with any two of the following:
- Antihypertensive medication and/or high blood pressure (≥140mmHg systolic or ≥90mmHg diastolic)
- Plasma triglycerides ≥150mg/dL (≥1.7mmol/L)
- HDL cholesterol <35mg/dL (0.9mmol/L) in men or <39mg/dL (1.0mmol/L) in women
- BMI (Body Mass Index) >30kg/m² and/or waist:hip ratio >0.9 in men, >0.85 in women
- Urinary albumin excretion rate ≥20μmg/g or albumin: creatinine ratio ≥30 mg/g.[3]
The metabolic syndrome is thus a cluster of risk factors for diabetes and cardiovascular diseases. The syndrome includes proinflammatory and prothrombotic features.[3]
The metabolic syndrome could also promote the development of cancer, polycystic ovary syndrome (PCOS), and nonalcoholic fatty liver disease".[4]
References
- ↑ ABC News: The World Is Getting Rounder. Retrieved on 2007-11-17.
- ↑ What Is Metabolic Syndrome?. Retrieved on 2007-11-17.
- ↑ 3.0 3.1 Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C (2004). "Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition". Arterioscler. Thromb. Vasc. Biol. 24 (2): e13–8. DOI:10.1161/01.ATV.0000111245.75752.C6. PMID 14766739. Research Blogging.
- ↑ Biddinger SB, Kahn CR (2006). "From mice to men: insights into the insulin resistance syndromes". Annu. Rev. Physiol. 68: 123–58. DOI:10.1146/annurev.physiol.68.040104.124723. PMID 16460269. Research Blogging.