Beta-2 adrenergic receptor

In medicine and physiology, beta-2 adrenergic receptors, or β-2 adrenergic receptors, are cell surface receptors of the G-protein-coupled receptor type that are in the sympathetic nervous system. Beta-2 adrenergic receptors are a "subclass of beta-adrenergic receptors (receptors, adrenergic, beta). Beta-2 Adrenergic receptors are more sensitive to epinephrine than to norepinephrine and have a high affinity for the agonist terbutaline. They are widespread, with clinically important roles in skeletal muscle, liver, and vascular, bronchial, gastrointestinal, and genitourinary smooth muscle." Their functions include vasodilation.

After binding, signal transduction activates the second messenger systems adenyl cyclase-cyclic AMP primarily and also cyclic GMP which then activates protein kinases.

Adrenergic beta-agonists, such as terbutaline, are used to treat asthma by preventing bronchoconstriction.